Traditional geotechnical analyses for landslides involve failure prediction (i.e. onset of failure) and the design of structures that can safely withstand the applied loads. The analyses provide limited information on the post-failure behaviour. Modern numerical methods are able to simulate large mass movements and there is an opportunity to utilise such methods to evaluate the risks of catastrophic damage if a landslide occurs. In this paper, various large-deformation analysis methods are introduced and their applicability for solving landslide problems is discussed. Since catastrophic landslides often involve seepage forces, consideration of the coupled behaviour of soil and pore fluid is essential. Two approaches to model soil–pore fluid coupling in large-deformation analysis using the material point method (MPM) are introduced. An example simulation is presented for each approach; one on a model levee failure and the other on a natural cut slope failure (the Selborne experiment conducted by Cooper and co-workers in 1998). In the levee failure case, MPM simulation was able to capture a complex failure mechanism including the development of successive shear bands. The simulation was also able to predict excess pore pressure generation during the failure propagation and the subsequent consolidation stage. The simulations demonstrated the importance of the dilation characteristics of soil as well as changes in geometry for the post-failure behaviour. In the Selborne case, MPM was able to simulate the progressive failure of brittle, overconsolidated clay. The evolution of shear stresses along the failure surface was also captured by the MPM. The changes in the pore pressure and the actual shape of the failure surface were simulated by the MPM. The importance of accurately modelling the shear band within the MPM framework is highlighted.

/pdf/trends-in-large-deformation-analysis-of-landslide-mass-1ss5r3u2tp.pdf

Trends in large-deformation analysis of landslide mass movements with particular emphasis on the material point method

Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypoxia affects both cancer and stromal cells. Exosomes are recognized as mediators of intercellular communication. Here, we aim to further elucidate the communication between BMSC-derived exosomes and cancer cells in the hypoxic niche. Exosomal miRNA profiling was performed using a microRNA array. Lung cancer cells and an in vivo mouse syngeneic tumor model were used to evaluate the effects of select exosomal microRNAs. Hypoxic BMSC-derived plasma exosomal miRNAs were assessed for their capacity to discriminate between cancer patients and non-cancerous controls and between cancer patients with or without metastasis. We demonstrate that exosomes derived from hypoxic BMSCs are taken by neighboring cancer cells and promote cancer cell invasion and EMT. Exosome-mediated transfer of select microRNAs, including miR-193a-3p, miR-210-3p and miR-5100, from BMSCs to epithelial cancer cells activates STAT3 signaling and increases the expression of mesenchymal related molecules. The diagnostic accuracy of individual microRNA showed that plasma exosomal miR-193a-3p can discriminate cancer patients from non-cancerous controls. A panel of these three plasma exosomal microRNAs showed a better diagnostic accuracy to discriminate lung cancer patients with or without metastasis than individual exosomal microRNA. Exosome-mediated transfer of miR-193a-3p, miR-210-3p and miR-5100, could promote invasion of lung cancer cells by activating STAT3 signalling-induced EMT. These exosomal miRNAs may be promising noninvasive biomarkers for cancer progression.

/pdf/hypoxic-bmsc-derived-exosomal-mirnas-promote-metastasis-of-5g6els7tuo.pdf

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

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Handbook Of Human Vibration

Prediction of ground vibration from trains using the wavenumber finite and boundary element methods

Research developments in vibration control of structures using passive tuned mass dampers

Coupled boundary and finite element analysis of vibration from railway tunnels—a comparison of two- and three-dimensional models

A numerical model for studying the dynamic evolution of landslides is presented. The numerical model is based on the Generalized Interpolation Material Point Method. A simplified slope with a house placed on top is analysed. An elasto-plastic material model based on the Mohr–Coulomb yield criterion is employed for the soil. The slide is triggered for the initially stable slope by removing the cohesion of the soil and the slide is followed from the triggering until a state of static equilibrium is again reached. Parameter studies, in which the angle of internal friction of the soil and the degree of discretisation are varied, are presented.

/pdf/modelling-of-landslides-with-the-material-point-method-3bxbbsv1jf.pdf

Lars Vabbersgaard Andersen

Papers

Coupled boundary and finite element analysis of vibration from railway tunnels—a comparison of two- and three-dimensional models

Modelling of Landslides with the Material-Point Method

Reduction of ground vibration by means of barriers or soil improvement along a railway track

Cross-wind modal properties of offshore wind turbines identified by full scale testing

Natural Frequencies of Wind Turbines on Monopile Foundations in Clayey Soils: A probabilistic approach