L
Laura A. Bass
Researcher at Washington University in St. Louis
Publications - 10
Citations - 1471
Laura A. Bass is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: In vivo & P-glycoprotein. The author has an hindex of 8, co-authored 10 publications receiving 1406 citations.
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Journal ArticleDOI
Efficient production of high specific activity 64Cu using a biomedical cyclotron.
Deborah W. McCarthy,R.E. Shefer,Robert E. Klinkowstein,Laura A. Bass,William H. Margeneau,Cathy S. Cutler,Carolyn J. Anderson,Michael J. Welch +7 more
TL;DR: It is shown that it is possible to separate Cu-64 from Ni-64 and other reaction byproducts rapidly and efficiently by using ion exchange chromatography.
Journal ArticleDOI
In vivo transchelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver.
TL;DR: Evaluating the metabolic fate of copper radiopharmaceuticals demonstrated that Cu(II) dissociates from macrocyclic chelators such as TETA and binds to proteins in high concentrations, namely SOD in rat liver.
Journal Article
64Cu-TETA-Octreotide as a PET Imaging Agent for Patients with Neuroendocrine Tumors
Carolyn J. Anderson,Farrokh Dehdashti,P. D. Cutler,Sally W. Schwarz,Richard Laforest,Laura A. Bass,Jason S. Lewis,Deborah W. McCarthy +7 more
TL;DR: It is shown that 64Cu-TETA-OC and PET can be used to detect somatostatin-receptor-positive tumors in humans and is a promising radiopharmaceutical for PET imaging of patients with neuroendocrine tumors.
Journal ArticleDOI
High purity production and potential applications of copper-60 and copper-61
Deborah W. McCarthy,Laura A. Bass,P.Duffy Cutler,R.E. Shefer,Robert E. Klinkowstein,Pilar Herrero,Jason S. Lewis,Cathy S. Cutler,Carolyn J. Anderson,Michael J. Welch +9 more
TL;DR: The tumor images obtained using 61Cu were found to be superior to those using 64Cu as predicted based on the larger abundance of positrons emitted by 61Cu vs. 64Cu.
Journal Article
Radiotherapy, Toxicity and Dosimetry of Copper-64-TETA-Octreotide in Tumor-Bearing Rats
Carolyn J. Anderson,Lynne Jones,Laura A. Bass,E. L. C. Sherman,Deborah W. McCarthy,P. D. Cutler,M. V. Lanahan,M. E. Cristel,Jason S. Lewis,Sally W. Schwarz +9 more
TL;DR: Copper-64-TETA-octreotide is a promising radiopharmaceutical for targeted radiotherapy of somatostatin receptor-positive tumors in Lewis rats and data indicate that radiotherapy with 64Cu-tetraacetic acid (TETA) in humans would be feasible.