L
Laura Silvestri
Researcher at Vita-Salute San Raffaele University
Publications - 86
Citations - 6390
Laura Silvestri is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Hepcidin & Erythropoiesis. The author has an hindex of 33, co-authored 71 publications receiving 5546 citations. Previous affiliations of Laura Silvestri include Università telematica San Raffaele.
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Journal ArticleDOI
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.
Maurizio De Fusco,Roberto Marconi,Laura Silvestri,Luigia Atorino,Luca Rampoldi,Letterio Morgante,Andrea Ballabio,Paolo Aridon,Giorgio Casari +8 more
TL;DR: Results show that mutations in the gene ATP1A2 that encodes the α2 subunit of the Na+/K+ pump are associated with familial hemiplegic migraine type 2 (FHM2) linked to chromosome 1q23 (OMIM 602481).
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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.
Laura Silvestri,Alessia Pagani,Antonella Nai,Ivana De Domenico,Jerry Kaplan,Clara Camaschella +5 more
TL;DR: The inhibitory effect of matriptase-2 on hepcidin promoter is confirmed and it is shown that matript enzyme-2 lacking the serine protease domain is fully inactive and that mutant R774C found in patients with genetic iron deficiency has decreased inhibitory activity.
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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
Laura Silvestri,Viviana Caputo,Emanuele Bellacchio,Luigia Atorino,Bruno Dallapiccola,Enza Maria Valente,Giorgio Casari +6 more
TL;DR: It is described that PINK1 mutations confer different autophosphorylation activity, which is regulated by the C-terminal portion of the protein, and the mitochondrial localization of both wild-type and mutant Pink1 proteins unequivocally.
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Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
TL;DR: It is shown that s-HJV originates from a furin cleavage at position 332-335, and that furin is up-regulated by iron deficiency and hypoxia in association with the stabilization of HIF-1alpha.
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Iron metabolism and iron disorders revisited in the hepcidin era
TL;DR: Improved understanding of iron homeostasis and its regulation is leading to the development of targeted therapies for iron overload and inflammation, mainly centered on the manipulation of the hepcidin-ferroportin axis.