Laure Avoscan

TL;DR: It is demonstrated that U is genotoxic from 300microM and induces caspase-dependent apoptosis cell death from 200microM mainly through the intrinsic pathway in NRK-52(E) cells, and suggests that the DNA damage caused by U is reversible at low concentration but becomes irreversible and leads to cell death for higher concentrations.

TL;DR: Results show that R. metallidurans CH34 may be suitable for the remediation of selenite- but not selenate- contaminated environments, and selenATE mostly follows an assimilatory pathway and the reduction pathway is not activated upon selenates exposure.

TL;DR: Computer modeling of uranyl Speciation is reported, enabling one to draw a parallel between uranyl speciation and its cytotoxicity, and the CI50 cytot toxicity index, the uranium concentration leading to 50% dead cells after 24 h of exposure, is 500 microM (+/-100 microM) and strongly depends on uranyl counterion and cell culture medium composition.

TL;DR: The aim of this research is to investigate the mechanisms of uranium toxicity, intracellular accumulation and repartition after acute intoxication of rat renal proximal tubule epithelial cells, as a function of its chemical form.

TL;DR: Results demonstrate that valid determinations of the Evalue of Se necessitate that the Se oxyanions are speciated in solution, and are clearly evident for these soils and sediments where it was observed that the Evalues of SeO3 and SeO4 represented, respectively, 5-97% and 3-95% of the total Se E value.