L
Lauren D. Black
Researcher at Tufts University
Publications - 72
Citations - 5336
Lauren D. Black is an academic researcher from Tufts University. The author has contributed to research in topics: Extracellular matrix & Tissue engineering. The author has an hindex of 27, co-authored 67 publications receiving 4514 citations. Previous affiliations of Lauren D. Black include University of Minnesota & Tufts Medical Center.
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Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction.
Kyle P. Quinn,Kelly E. Sullivan,Zhiyi Liu,Zachary S. Ballard,Christos Siokatas,Christos Siokatas,Irene Georgakoudi,Lauren D. Black +7 more
TL;DR: It is indicated that cross-linking plays a key role in stiffness at the collagen fiber level following infarction, and how this non-destructive approach to assessing remodeling can be used to understand ECM structure-function relationships is highlighted.
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Beta 1 integrin binding plays a role in the constant traction force generation in response to varying stiffness for cells grown on mature cardiac extracellular matrix
TL;DR: The data demonstrates that cells grown on the mature cardiac ECM are able to circumvent typical stiffness related cellular behaviors, likely through β1 integrin binding to the complex composition.
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Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices
TL;DR: It is concluded that not only the presence but the dynamic nature of mechanical forces have a significant impact on enzyme activity, hence the deterioration of the functional properties of the ECM during exposure to enzymes.
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Cardiac Fibroblasts Support Endothelial Cell Proliferation and Sprout Formation but not the Development of Multicellular Sprouts in a Fibrin Gel Co-Culture Model
TL;DR: Overall, CFs provide a good support system for EC proliferation and sprout formation; however, MSCs allow for more multicellular sprouts, which is more indicative of the in vivo process.
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Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro
TL;DR: It is suggested that depolarization maintains postnatal CM proliferation and may be a novel approach to encourage growth of engineered tissue and cardiac regeneration in pediatric patients.