L
Lauren M. Kim
Researcher at Cornell University
Publications - 2
Citations - 447
Lauren M. Kim is an academic researcher from Cornell University. The author has contributed to research in topics: Germline mutation & Point mutation. The author has an hindex of 2, co-authored 2 publications receiving 418 citations.
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Journal ArticleDOI
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer’s disease brain
TL;DR: It is found that brain mtDNA from elderly subjects had a higher aggregate burden of mutations than brain mt DNA from younger subjects, and Cytochrome oxidase activity correlated negatively with increasing mutational burden.
Journal ArticleDOI
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
David Simon,Michael T. Lin,Leiya Zheng,Guang-Jun Liu,Colette H. Ahn,Lauren M. Kim,William M. Mauck,Florence Twu,M. Flint Beal,Donald R. Johns +9 more
TL;DR: The results indicate that individually rare mtDNA point mutations reach a high aggregate burden in FCtx and SN of elderly subjects and there were no significant differences between Parkinson's disease patients and age-matched controls in somatic mutation levels.