L
Laurie L. Kenney
Researcher at University of Massachusetts Medical School
Publications - 15
Citations - 924
Laurie L. Kenney is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Immune system & CD8. The author has an hindex of 12, co-authored 15 publications receiving 724 citations.
Papers
More filters
Journal ArticleDOI
Humanized Mouse Models of Clinical Disease.
Nicole C. Walsh,Laurie L. Kenney,Sonal Jangalwe,Ken-Edwin Aryee,Dale L. Greiner,Michael A. Brehm,Leonard D. Shultz +6 more
TL;DR: Recent progress in the development and use of humanized mice is discussed and their utility for the study of human diseases is highlighted.
Journal ArticleDOI
Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Michael A. Brehm,Laurie L. Kenney,Michael V. Wiles,Benjamin E. Low,Roland Tisch,Lisa M. Burzenski,Christian Mueller,Dale L. Greiner,Leonard D. Shultz +8 more
TL;DR: The data document that NSG mice deficient in murine MHC support studies of human immunity in the absence of acute GVHD and enable evaluation of human antibody therapeutics targeting human T cells.
Journal ArticleDOI
Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.
Markus Cornberg,Laurie L. Kenney,Alex T. Chen,Stephen N. Waggoner,Sung-Kwon Kim,Hans Peter Dienes,Raymond M. Welsh,Liisa K. Selin +7 more
TL;DR: For non-cytopathic viruses like LCMV, hepatitis C virus, and hepatitis B virus, clonal exhaustion may be a protective mechanism preventing severe immunopathology and death, as demonstrated with three different inocula of lymphocytic choriomeningitis virus.
Journal ArticleDOI
Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Paul J. Bryce,Rustom Falahati,Laurie L. Kenney,John Leung,Christopher R. Bebbington,Nenad Tomasevic,Rebecca Krier,Chia-Lin Hsu,Leonard D. Shultz,Dale L. Greiner,Michael A. Brehm +10 more
TL;DR: NSG-SGM3 BLT mice provide a readily available source of human mast cells for investigation of mast cell biology and a preclinical model of passive cutaneous anaphylaxis and passive systemic anaphYLaxis that can be used to investigate the pathogenesis of human allergic responses and to test new therapeutics before their advancement to the clinic.
Journal ArticleDOI
Humanized Mouse Models for Transplant Immunology.
TL;DR: A review of recent advances in the development of humanized mice and their use as preclinical models for the study of human allograft responses highlights an important preclinical model system for evaluation of new drugs and identification of the mechanisms underlying humanAllograft rejection without putting patients at risk.