R
Rustom Falahati
Researcher at University of California, San Francisco
Publications - 24
Citations - 729
Rustom Falahati is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 13, co-authored 24 publications receiving 567 citations. Previous affiliations of Rustom Falahati include Washington University in St. Louis & Medical Research Council.
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Journal ArticleDOI
Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76–ADAP
TL;DR: The data indicate that TCR‐mediated ROS generation leads to SHP‐2 oxidation, which promotes T‐cell adhesion through effects on an SLP‐76‐dependent signaling pathway to integrin activation.
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Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention
William M. Gwinn,Jesse M. Damsker,Rustom Falahati,Ifeanyi Okwumabua,Ann E. Kelly-Welch,Achsah D. Keegan,Christophe Vanpouille,James J. Lee,Lindsay A. Dent,David Leitenberg,Michael Bukrinsky,Stephanie L. Constant +11 more
TL;DR: It is proposed that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses, providing a novel mechanism whereby asthmatic lung inflammation may be reduced.
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Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.
Bradford A. Youngblood,Emily C. Brock,John Leung,Rustom Falahati,Bruce S. Bochner,Henrik S. Rasmussen,Kathryn A. Peterson,Christopher R. Bebbington,Nenad Tomasevic +8 more
TL;DR: A role for both MCs and eosinophils in EGID pathogenesis is suggested and the evaluation of anti-Siglec-8 as a therapeutic approach that targets both eos inophils and MCs is supported.
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Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Paul J. Bryce,Rustom Falahati,Laurie L. Kenney,John Leung,Christopher R. Bebbington,Nenad Tomasevic,Rebecca Krier,Chia-Lin Hsu,Leonard D. Shultz,Dale L. Greiner,Michael A. Brehm +10 more
TL;DR: NSG-SGM3 BLT mice provide a readily available source of human mast cells for investigation of mast cell biology and a preclinical model of passive cutaneous anaphylaxis and passive systemic anaphYLaxis that can be used to investigate the pathogenesis of human allergic responses and to test new therapeutics before their advancement to the clinic.
Journal ArticleDOI
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Bradford A. Youngblood,Emily C. Brock,John Leung,Rustom Falahati,Paul J. Bryce,Jessica M. Bright,Jason Williams,Leonard D. Shultz,Dale L. Greiner,Michael A. Brehm,Christopher R. Bebbington,Nenad Tomasevic +11 more
TL;DR: Human tissue selectivity of AK002 is examined and AK002 selectively evokes potent apoptotic and ADCC activity against eosinophils and prevents systemic anaphylaxis through mast cell inhibition.