Thevetia peruviana is a large flowering shrub in the Apocynaceae family used medicinally. The current study aims to determine the phytochemicals and antimicrobial potential of T. peruviana. GC-MS was used to screen the ethanol and n-hexane extracts. Leaf extracts (ethanol and hexane) revealed alkaloids, phenols, anthraquinones, cardiac glycosides, flavonoids, tannins, steroid glycosides, carbohydrates, proteins, terpenoids, terpenoids and fixed oils and fats. GC-MS analysis of the ethanol and hexane extract revealed 24 bioactive metabolites. T. peruviana leaf extracts inhibited tested pathogens at 50, 100, and 200 mg/ml concentrations. A plethora of secondary metabolites demonstrated promising pharmacological benefits. The bioactive chemicals are utilised to treat bacterial infections, cancer, diabetes, and inflammation. This study demonstrated the antibacterial activity of several plants used in traditional medicine.

Antibacterial, phytochemical and GC-MS analysis of Thevetia peruviana extracts: An approach in drug formulation

Physicochemical and Pharmacological Properties of Palm Oil: an Approach for Quality, Safety, and Nutrition Evaluation of Palm Oil

The main objective of the experiment is aimed to examine the impact of paraquat dichloride on the body weights of adult male Wistar rats as well as in their haematological tissues. The total number of male Wistar rats was 48 and was divided into 4 groups of 12 each. The 1st group (Test 1) served as control. The other three groups served as experimental groups in which the paraquat dichloride was administered. The experimental groups which are 2nd group (Test 2), 3rd group (Test 3) and 4th group (Test 4) received doses of paraquat dichloride of 10 mg/kg b.wt/per oral/day, 20 mg/kg b.wt/per oral/day and 40 mg/kg b.wt/per oral/day respectively. The experiment was carried out for a time duration of 42 days. The mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentrations were significantly (P<0.05) decreased in Test 2, 3 and 4 rats, excluding packed cell volume (PCV), which in comparison to the control groups. Outcomes and observations from hematological parameters and bone marrow revealed the toxicity of paraquat dichloride to hematological tissues resulting in anemia and bone marrow hypoplasia which eventually leads to failure of the bone marrow and extensively hematopoietic system of adult male Wistar rats following long term exposure and high concentration.

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Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Physicochemical, Phytochemical, Antioxidant, and Inhibition Properties of Key Enzymes Linked to Raw and Regular Honey

This research work investigated the proximate and nutritional composition of beer produced using sorghum blended with hybrid yellow cassava. Hybrid sorghum variety CSR-03H and two yellow cassava varieties were collected, and proximate and nutritional analysis was performed using standard methods. The sorghum malt was combined with yellow cassava varieties (in the order cassava: sorghum) at ratio 0:100 (control), 20:80, 30:70, 40:60 and 50:50. Fermentation of the samples was done for ten (10) days and analysis was performed every two (2) days interval. Proximate and nutritional analysis was carried out on the beer products using standard methods. After 240 h fermentation period, the pH and alcohol content ranged from 3.65 ± 0.01 to 4.10 ± 0.01 and from 3.63 ± 0.49% to 6.74 ± 0.41% respectively. Fat content, ash content, moisture content and crude protein values ranged from 0.30 ± 0.01% to 0.59 ± 0.01%, 0.42 ± 0.01% to 0.61 ± 0.02%, 76.10 ± 0.06% to 80.97 ± 0.02% and 0.30 ± 0.01% to 0.56 ± 0.01% respectively. Vitamin A and vitamin C content ranged from 12.38 ± 0.02 to 4.13 ± 0.02 μg/100 ml and 12.21 ± 0.04 to 17.39 ± 0.02 mg/100 ml respectively. The energy value of the products ranged from 124.74 ± 1.99 to 216.67 ± 1.96 KJ/100 ml. The study revealed that beer produced from sorghum blended with yellow cassava could be a rich source of nutrients and vitamins if employed as raw materials for beer production. • Beer produced from sorghum blended with yellow cassava is a rich source of nutrients and vitamins. • Protein content of substrate used for beer production has a great impact. • The alcoholic content of the beer increased during the fermentation period. • Yellow cassava contains higher levels of vitamin A when compared to sorghum. 

Proximate and nutritional composition of beer produced from malted sorghum blended with yellow cassava

s This research was conducted to examine the effect of vernonia amygdalina on Glutathione reductase and Glutathione-S-transferase in alloxan induced diabetic wistar rats. Sixty-six (66) adult male wistar rats weighing between 100 and 250 g were used for the study. The animals were induced by intraperitoneal injection of 60 mg of alloxan. The animals were divided into 11 groups of six (6) rats in phase 1 and phase 2 (normal control, crude extract, Metformin, glycoside, saponin and alkaloid) respectively. After 28days treatment, the rats were sacrificed using a gaseous anesthetic agent (chloroform), blood samples were collected from inferior Vena Cava for biochemical analysis and pancreas harvested for histopathological examination. The final fasting blood glucose level of the experimental animals showed no significant difference when compared to that of the control rats (at p

Effects of vernonia amygdalina fractionate on glutathione reductase and glutathione-S-transferase on alloxan induced diabetes wistar rat

An inventory of medicinal plants used as sedative, analgesic and blood tonic in Abeokuta, Ogun State, Nigeria

Alcohol intake, particularly to cope up with stress and depression experienced by commercial drivers during the peak of the COVID-19 pandemic, is alarming as a rise in sales has been reported in certain countries during the quarantine. Alcoholism leads to malnutrition, either because those involved consume an insufficient amount of essential nutrients or because alcohol and its metabolism prevent the body from properly absorbing, digesting, and using those nutrients. This study was carried out to assess the association of alcohol use and dietary lifestyle of commercial motor drivers during the pandemic.The anthropometric studies revealed that 69.5% of the respondents fall within the range of 18.5-24.49 indicating that they have normal weights. 63.5% reported daily consumption of alcohol, and 51% claimed that it does not affect their appetite, while 64.5% of the respondent stated that alcohol does not present them with any health problems. There was no significant association between the consumption of alcohol and nutritional status (p > 0.05), but a significant association between dietary lifestyle patterns and the nutritional status of participants was recorded (p < 0.05).It is, therefore, essential that commercial drivers are given adequate information and guidance on improving their dietary lifestyle. 

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Association of alcohol use and dietary lifestyle of commercial drivers during the COVID-19 pandemic in Nigeria

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Laurine Chikodiri Nwosu

Papers

Effects of vernonia amygdalina fractionate on glutathione reductase and glutathione-S-transferase on alloxan induced diabetes wistar rat

Physicochemical and Pharmacological Properties of Palm Oil: an Approach for Quality, Safety, and Nutrition Evaluation of Palm Oil

An inventory of medicinal plants used as sedative, analgesic and blood tonic in Abeokuta, Ogun State, Nigeria

Association of alcohol use and dietary lifestyle of commercial drivers during the COVID-19 pandemic in Nigeria

Association of alcohol use and dietary lifestyle of commercial drivers during the COVID-19 pandemic in Nigeria