L
Lawrence E. Williams
Researcher at University of Texas MD Anderson Cancer Center
Publications - 163
Citations - 4942
Lawrence E. Williams is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Squirrel monkey & Saimiri boliviensis. The author has an hindex of 33, co-authored 161 publications receiving 4607 citations. Previous affiliations of Lawrence E. Williams include University of Texas at Austin & University of Texas Health Science Center at Houston.
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Journal Article
Silencing of CXCR4 blocks breast cancer metastasis
Zhongxing Liang,Younghyoun Yoon,John R. Votaw,Mark M. Goodman,Lawrence E. Williams,Hyunsuk Shim +5 more
TL;DR: It is shown that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model, suggesting a novel preventive and therapeutic strategy for cancer management.
Journal Article
124I-Labeled Engineered Anti-CEA Minibodies and Diabodies Allow High-Contrast, Antigen-Specific Small-Animal PET Imaging of Xenografts in Athymic Mice
Gobalakrishnan Sundaresan,Paul J. Yazaki,John E. Shively,Ronald D. Finn,Steven M. Larson,Andrew Raubitschek,Lawrence E. Williams,Arion F. Chatziioannou,Sanjiv S. Gambhir,Anna M. Wu +9 more
TL;DR: I labeling of engineered antibody fragments provides a promising new class of tumor-specific probes for PET imaging of tumors and metastases in mice using a high-resolution small-animal PET system.
Journal ArticleDOI
High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
Anna M. Wu,Paul J. Yazaki,Shih-wa Tsai,Khoi Nguyen,Anne-Line Anderson,Deborah W. McCarthy,Michael J. Welch,John E. Shively,Lawrence E. Williams,Andrew Raubitschek,Jeffrey Y.C. Wong,Tatsushi Toyokuni,Michael E. Phelps,Sanjiv S. Gambhir +13 more
TL;DR: Engineered antibody fragments labeled with positron-emitting isotopes such as copper-64 provide a new class of agents for PET imaging of tumors.
Journal Article
Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.
Vania E. Kenanova,Tove Olafsen,Desiree Crow,Gobalakrishnan Sundaresan,Murugesan Subbarayan,Nora H. Carter,David Ikle,Paul J. Yazaki,Arion F. Chatziioannou,Sanjiv S. Gambhir,Lawrence E. Williams,John E. Shively,David Colcher,Andrew Raubitschek,Anna M. Wu +14 more
TL;DR: In this paper, the Fc-FcRn binding site of chimeric anti-carcinoembryonic antigen (CEA) antibodies produced in a single-chain Fv-fc format was mutated to modulate the half-life of engineered antibodies.
Journal ArticleDOI
Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications.
Tove Olafsen,Chia-Wei Cheung,Paul J. Yazaki,Lin Li,Gobalakrishnan Sundaresan,Sanjiv S. Gambhir,Mark A. Sherman,Lawrence E. Williams,John E. Shively,Andrew Raubitschek,Anna M. Wu +10 more
TL;DR: The cysteine-modified diabody (Cys-diabody) provides a covalently linked alternative to conventional diabodies, which can be reduced and modified site-specifically and will provide a versatile platform for targeting a variety of agents to CEA-positive tumors.