H
Hyunsuk Shim
Researcher at Emory University
Publications - 140
Citations - 8124
Hyunsuk Shim is an academic researcher from Emory University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 42, co-authored 129 publications receiving 7291 citations. Previous affiliations of Hyunsuk Shim include Johns Hopkins University School of Medicine & Georgia State University.
Papers
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Journal ArticleDOI
c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
Hyunsuk Shim,Christine Dolde,Brian C. Lewis,Chyi Sun Wu,Gerard Dang,Richard A. Jungmann,Riccardo Dalla-Favera,Chi V. Dang +7 more
TL;DR: It is suggested that an increased LDH-A level is required for the growth of a transformed spheroid cell mass, which has a hypoxic internal microenvironment and is necessary for c-Myc-mediated transformation.
Journal ArticleDOI
Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc
Rebecca C. Osthus,Hyunsuk Shim,Sunkyu Kim,Qing Li,Rahul Reddy,Mita Mukherjee,Yi Xu,Diane R. Wonsey,Linda A. Lee,Chi V. Dang +9 more
TL;DR: Findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway.
Journal Article
Silencing of CXCR4 blocks breast cancer metastasis
Zhongxing Liang,Younghyoun Yoon,John R. Votaw,Mark M. Goodman,Lawrence E. Williams,Hyunsuk Shim +5 more
TL;DR: It is shown that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model, suggesting a novel preventive and therapeutic strategy for cancer management.
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Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4.
Zhongxing Liang,Tao Wu,Hong Lou,Xiwen Yu,Russell S. Taichman,Stephen K. Lau,Shuming Nie,Jay N. Umbreit,Hyunsuk Shim +8 more
TL;DR: The role of a synthetic antagonist 14-mer peptide (TN14003) in inhibiting metastasis of breast cancer by inhibiting migration is investigated and may prove useful as a diagnostic tool to identify CXCR4 receptor-positive tumor cells in culture and tumors in paraffin-embedded clinical samples.
Journal ArticleDOI
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Zhongxing Liang,Hui Wu,James Xia,Yuhua Li,Yawei Zhang,Yawei Zhang,Ke Huang,Nicholas Wagar,Younghyoun Yoon,Heidi T. Cho,Stefania Scala,Hyunsuk Shim +11 more
TL;DR: Findings demonstrate for the first time the involvement of miRNAs in multidrug resistance mediated by MRP-1 and suggest that miR-326 may be an efficient agent for preventing and reversing MDR in tumor cells.