L
Lawrence M. Sayre
Researcher at Case Western Reserve University
Publications - 174
Citations - 15502
Lawrence M. Sayre is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Amine oxidase & Oxidative stress. The author has an hindex of 53, co-authored 174 publications receiving 14905 citations. Previous affiliations of Lawrence M. Sayre include Montana State University & Asahikawa Medical University.
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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
TL;DR: It is found, using a modified histochemical technique that relies on the formation of mixed valence iron complexes, that redox-active iron is associated with the senile plaques and neurofibrillary tangles-the pathological hallmark lesions of Alzheimer disease.
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Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
TL;DR: There is strong evidence that peroxynitrite is involved in oxidative damage of Alzheimer’s disease, and the widespread occurrence of nitrotyrosine in neurons suggests that oxidative damage is not restricted to long-lived polymers such as NFTs, but instead reflects a generalized oxidative stress that is important in disease pathogenesis.
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4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
Lawrence M. Sayre,Dawn A. Zelasko,Peggy L.R. Harris,George Perry,Robert G. Salomon,Mark A. Smith +5 more
TL;DR: The known neurotoxicity of HNE suggests that lipid peroxidation may also play a role in the neuronal death in AD that underlies cognitive deficits.
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Oxidative damage in Alzheimer's
Mark A. Smith,George Perry,P. L. Richey,Lawrence M. Sayre,Vernon E. Anderson,M.F. Beal,Neil W. Kowall +6 more
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Oxidative stress and neurotoxicity
TL;DR: The role of oxidative Stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death is highlighted.