L
Lawrence S. Melvin
Researcher at Pfizer
Publications - 76
Citations - 6700
Lawrence S. Melvin is an academic researcher from Pfizer. The author has contributed to research in topics: Alkyl & Cannabinoid. The author has an hindex of 22, co-authored 76 publications receiving 6447 citations.
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Patent
Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
TL;DR: Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in synthesis thereof as mentioned in this paper.
Journal Article
Structural studies leading to the discovery of a cannabinoid binding site.
Patent
Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof
TL;DR: Tricyclic benzo fused compounds of the formula "STR1##" and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or two; M is CH or N, R1 is H or certain acyl groups; Q is CO2 R4, COR5, C(OR7)R5 R6, CN, CONR9 R10, CH2 NR 9 R10 and CH2 NHCOR11, CH 2 NHSO2 R12, 5
Patent
9-Hydroxyhexahydrodibenzo[O,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo[b,d]pyrans and intermediates therefor
TL;DR: In this paper, the synthesis of 9-ketones is discussed, where the substituent is hydrogen, methyl, hydroxymethyl, formyl, carboxy, carbamyl, amino, mono-and di-alkylamino, alkanoylamino and phenalkylsulfonamido.
Patent
Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
TL;DR: In this article, the authors describe the properties of leukotrienes for the treatment of asthma, arthritis, and related diseases mediated by leukocyte mediated leukocytosis.