Le Zhang Day

TL;DR: There are mechanistically distinct roles for gH/gL/gO in cell-free and cell-to-cell spread, gO isoforms can differentially shield the virus from neutralizing antibodies, and effects of gO polymorphisms are epistatically dependent on other variable loci.

TL;DR: By measuring the kinetics of spread at early time points, this work was able to show that HCMV strains can be highly specialized to either cell-free or cell-to-cell mechanisms, and this was not strictly linked the efficiency of cell- free spread.

TL;DR: Data indicate that myeloid MLKL restricts ethanol-induced liver inflammation and injury by regulating hepatic immune cell homeostasis and macrophage phagocytosis.

TL;DR: In this paper, the authors characterized a panel of gL mutants by transient expression and showed that many were impaired for gH/gL/gO-gB-dependent cell-cell fusion but were still able to form gH, gL/pUL128-131 and induce receptor interference.

TL;DR: In this article, the authors investigated how natural interstrain variation in the amino acid sequence of gO influences the biology of HCMV and found that gO diversity can have dramatic impacts on cell-free and cell-to-cell spread as well as on antibody neutralization and the manifestation of these impacts can be subject to epistatic influences of the global genetic background.