Leah McNally

TL;DR: An overview of how inflammation and glutamate dysfunction contribute to the pathophysiology of depression is provided and microglia activated by excess inflammation, astroglial loss, and inappropriate glutamate receptor activation ultimately disrupt the delicate balance of neuroprotective versus neurotoxic effects in the brain.

TL;DR: It is demonstrated that a cleavage-resistant form of TUG does not support highly insulin-responsive GLUT4 translocation or glucose uptake in 3T3-L1 adipocytes, and it is shown using RNAi that TC10α is required for TUG proteolytic processing.

TL;DR: A model in which TUG acetylation modulates its interaction with Golgi matrix proteins and is regulated by SIRT2 is supported, which promotes GLUT4 accumulation in insulin-responsive vesicles and enhances insulin-stimulated glucose uptake.

TL;DR: In apparent early stage ovarian cancer, the presence of isolated omental metastases is relatively rare, and in cases where adjuvant chemotherapy is planned, the role of omentectomy appears to be primarily for staging, while its therapeutic role remains unclear in microscopic omental disease.

TL;DR: Performance of omentectomy in patients with EOC without bulky disease (≤stage IIIA) did not seem to confer improvement in survival, and a randomized control trial would be needed to fully address this question.