PURPOSE: A pharmaceutical composition containing secondary amine-substituted benzopyrane derivative is provided to prevent or treat macular degeneration CONSTITUTION: A pharmaceutical composition for preventing or treating macular degeneration contains a compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient The composition is used in the form of eye drops and the active ingredients are delivery to retina Eye drops for preventing or treating macular degeneration contain the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient A pharmaceutical composition for preventing or treating macular degeneration contains (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyrane or pharmaceutically acceptable salt thereof as an active ingredient

Pharmaceutical composition for prevention or treatment of macular degeneration

Disclosed is an event communication apparatus for a protection relay, which effectively simplifies an event determination operation by a main processing module and a communication module, thereby enhancing updating. The event communication apparatus for the protection relay includes a shared memory configured to store and provide data needed to share, a main processing module configured to, whenever an event occurs, update previous event data to a status information of the event and a status occurrence time information as new event data, and write the updated event data into the shared memory, and a communication module configured to periodically read status information from the shared memory, compare the read status information with pre-stored previous status information to determine whether there is a status change, determine occurrence of a new event when there is the status change, and transmit corresponding event data to an supervisory monitor immediately when the new event occurs.

Event communication apparatus for protection relay

A device and a method for controlling the pitch angle of a propeller are disclosed According to one aspect of the present embodiment, one objective of the present invention is to provide the device and the method, which calculate the pitch angle at which the propeller has maximum efficiency, despite a change in the number of revolutions of a propeller and an irregular speed of a ship, thereby controlling the pitch angle of the propeller such that the propeller has the corresponding pitch angle

Device and method for controlling pitch angle of propeller

The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.

Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation

The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.

Benzopyran derivatives substituted with a benzimidazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them

PURPOSE: Benzopyran derivatives substituted by secondary amine containing imidazole and a method for preparing the same are provided. The compounds are useful for treatment of cancer, diabetic retinopathy and external brain wound. CONSTITUTION: Benzopyran derivatives substituted by secondary amine containing imidazole represented by the formula(1), partial stereo isomers thereof and pharmaceutically acceptable salts thereof are provided, wherein R1 is H, CN, NO2 or NH2; R2 is CH3, CHORaRa or CHOOZ; Ra is C1-C4 linear or branched chain alkyl; Z is C2-C6 linear or branched chain alkyl; R3 and R4 are independently H, Cl, Br, F, C1-C3 linear or branched chain alkyl, ORb, CF3, OCF3, NO2 or CO2Rb; Rb is H or C1-C3 alkyl; and * is chiral carbon. A method for preparing the compound of the formula(I) comprises reacting epoxide compounds of the formula(II) with imidazole containing secondary amine compounds of the formula(III) in the presence of metal salt and a solvent, wherein the metal salt is selected from Mg(ClO4)2, COCl2, LiClO4, NaClO4, CaCl2, ZnCl2, LiBF4 and Zn(Tf)2; and the solvent is selected from acetonitrile, tetrahydrofuran and dimethylformamide.

Benzopyran derivatives substituted with secondary amines including imidazole and their preparation

PURPOSE: A communication dualization apparatus of a controllable pitch propulsion control system is provided to improve a communication function by inactivating a communication channel when a problem is generated in the communication channel. CONSTITUTION: A communication channel is changed into a dualization channel between the communication module of a main controller(10) and the communication channel of control heads(20-1~20-n). The main controller and the communication module of the control head monitor a communication state. When a problem is generated in an activated communication channel, the activated channel is inactivated and a standby communication channel is activated at the same time. Alarm is generated when the problem is generated in the activated communication channel.

Dual communication unit of cpp control system

PURPOSE: A communication module and data communication method for a digital protective relay are provided to sufficiently perform an inherent function of a digital protective relay. CONSTITUTION: A communication module for a digital protective relay includes a HDLC protocol(100), a shared memory(200), a multiplexer(300), a communication unit(400) and an interrupt(500). The HDLC protocol transceives data by performing half duplex communication with an upper monitoring system. The shared memory transceives data with the HDLC protocol and provides a bidirectional interface. The multiplexer transceives data with the shared memory and transmits the signal by selecting one input signal by a selected control signal in a plurality of circuit input signals. The communication unit transceives data with the multiplexer and transceives data with a desktop and a controller by performing communication. The interrupt transmits a single signal with respect to one communication packet received in the HDLC to the control unit.

Data communication method for communication module of digital protective relay

PURPOSE: An apparatus and a method for controlling the main engine RPM of a CPP control system are provided to enable a driver to confirm the RPM and load state of a main engine through a master control head. CONSTITUTION: An apparatus for controlling the main engine RPM of a CPP control system comprises a master control head, a main controller, and a main engine controller. An RPM control value for controlling the RPM of a main engine is inputted to the master control head through an engine RPM lever(S10). The master control head sends the inputted RPM control value to the main controller. The main controller converts the RPM control value into an analog value and sends the analog value to the main engine controller(S16). The main engine controller controls the RPM of the main engine based on the received analog value and transmits the RPM state signal of the main engine to the main controller in real time(S20).

Lee Byeong Ho

Papers

Benzopyran derivatives substituted with secondary amines including imidazole and their preparation

Dual communication unit of cpp control system

Data communication method for communication module of digital protective relay

Apparatus and method for controlling main engine rpm of cpp control system