PURPOSE: A pharmaceutical composition containing secondary amine-substituted benzopyrane derivative is provided to prevent or treat macular degeneration CONSTITUTION: A pharmaceutical composition for preventing or treating macular degeneration contains a compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient The composition is used in the form of eye drops and the active ingredients are delivery to retina Eye drops for preventing or treating macular degeneration contain the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient A pharmaceutical composition for preventing or treating macular degeneration contains (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyrane or pharmaceutically acceptable salt thereof as an active ingredient

Pharmaceutical composition for prevention or treatment of macular degeneration

The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.

Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation

The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.

Benzopyran derivatives substituted with a benzimidazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them

A 2,2'-alkylsubstitued-3,4-dehydro-6-alkylamino benzopyran derivative is provided to secure the activity of controlling neuronal death by controlling the activity of a glutamate receptor, thereby being useful as a prophylactic and therapeutic agent of stroke, epilepsy, amyotrophic lateral sclerosis, Parkinson's diseases, Huntington's disease and Alzheimer's disease. A pharmaceutical composition comprises a 2,2'-double substituted-7,8-double substituted-6-alkylamino benzopyran derivative represented by the formula(1) or a pharmaceutically acceptable salt thereof. In the formula(1), R^1 is C1-10 alkyl, benzyl, or substituted benzyl, phenethyl, 2-pyrimidylmethyl, thiophene, 2-methylthiophenemethyl, 5-methyl-2-thiophenemethyl, 3-thiophenemethyl, indolylmethyl, benzo dioxiranylmethyl, naphthalenylmethyl, or furanylmethyl, each R^2 and R^3 is H, C1-6 alkyl, halogen, or phenyl and substituted phenyl, R^4 is C1-10 alkyl, phenyl or substituted phenyl, or a hetero-cyclic group selected from the group consisting of thiophene and furan(wherein the benzyl, phenyl or the heterocyclic group is able to be substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, nitro, cyano and C1-6 alkoxy), and n is an integer from 1 to 5.

2,2'-alkyisubstituted-3,4-dehydro-6-alkylamino benzopyran derivatives as protection agents for cerebral cell death

PURPOSE: Benzopyran derivatives substituted by secondary amine containing imidazole and a method for preparing the same are provided. The compounds are useful for treatment of cancer, diabetic retinopathy and external brain wound. CONSTITUTION: Benzopyran derivatives substituted by secondary amine containing imidazole represented by the formula(1), partial stereo isomers thereof and pharmaceutically acceptable salts thereof are provided, wherein R1 is H, CN, NO2 or NH2; R2 is CH3, CHORaRa or CHOOZ; Ra is C1-C4 linear or branched chain alkyl; Z is C2-C6 linear or branched chain alkyl; R3 and R4 are independently H, Cl, Br, F, C1-C3 linear or branched chain alkyl, ORb, CF3, OCF3, NO2 or CO2Rb; Rb is H or C1-C3 alkyl; and * is chiral carbon. A method for preparing the compound of the formula(I) comprises reacting epoxide compounds of the formula(II) with imidazole containing secondary amine compounds of the formula(III) in the presence of metal salt and a solvent, wherein the metal salt is selected from Mg(ClO4)2, COCl2, LiClO4, NaClO4, CaCl2, ZnCl2, LiBF4 and Zn(Tf)2; and the solvent is selected from acetonitrile, tetrahydrofuran and dimethylformamide.

Benzopyran derivatives substituted with secondary amines including imidazole and their preparation

PURPOSE: A process for preparing tetrazole derivatives is provided, thereby preparing the tetrazole derivatives useful in the prevention of hypertension caused by angiotensin II under mild condition. CONSTITUTION: A process for preparing tetrazole derivatives of the formula(I) comprises reacting a compound of the formula(II) with a compound of formula(III) in an organic solvent in the presence of a metal catalyst, wherein Ar is A-ring, 1-naphthyl or 2-naphthyl; A is hydrogen, linear chain, branched chain or cyclic C1-C6 alkyl, phenyl, halogen, OR, CH2OR or CON(R)2; R is C1-C4 alkyl or benzyl; P is benzyl; Met is B(OH)2 or Sn(R')3; R' is C1-C4 alkyl; the organic solvent is selected from the group consisting of benzene, toluene, tetrahydrofuran, dioxane, acetonitrile, dimethylformamide, methanol and ethanol; the reaction temperature ranges from the room temperature to 150 deg. C; the amount of the metal catalyst used is 1 to 10 mole%; and the metal catalyst is a chelate of palladium, nickel or platinum.

Seo Ji Hui

Papers

Benzopyran derivatives substituted with secondary amines including imidazole and their preparation

Process for preparing tetrazole derivatives