Showing papers by "Leelavinothan Pari published in 2019"
TL;DR: It is suggested that myrtenal may serve as an antioxidant and anti-inflammatory agent against diabetes-associated oxidative stress and inflammation against a rat model of streptozotocin-induced diabetes.
Abstract: The present study was aimed to investigate the effect of myrtenal on diabetes-associated oxidative stress, lipid peroxidation (LPO), and inflammation using a rat model of streptozotocin (STZ)-induc...
6 citations
TL;DR: Oral administration of pterostilbene significantly improved the glycoprotein levels in plasma and tissues of diabetic mice to near normal level and resolved that PTS improves disturbed glycop protein metabolism in HFD and STZ-induced type 2 diabetic mice.
Abstract: Objective: The aim of the current study is to evaluate the effect of pterostilbene (PTS), on deranged plasma and tissue glycoprotein components in high-fat-diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice.
Methods: The experimental duration was 16 weeks. The C57BL6/J mice were fed a normal diet, normal diet with PTS, HFD, and STZ injection (10th week only), and diabetic mice with PTS for the past 6 weeks.
Results: A significant increase in glycoprotein components such as hexose, hexosamine, fucose, and sialic acid (SA) in plasma was observed in diabetic mice. In hepatic and renal tissues, a significant decrease in SA with an increase in other glycoprotein components was detected in diabetic mice when compared with control mice. Oral administration of PTS significantly improved the glycoprotein levels in plasma and tissues of diabetic mice to near normal level.
Conclusion: In this study, we resolved that PTS improves disturbed glycoprotein metabolism in HFD and STZ-induced type 2 diabetic mice.
2 citations
01 May 2019
TL;DR: Type 2 diabetes mellitus is a metabolic disorder that reduces the body's ability to glucose uptake and leads to hyperglycemia, blood lipid disorders, including hypertriglyceridemia and low HDL-cholesterol and increased oxidative stress.
Abstract: Diabetes is a common disease in the whole world, which has an increasing prevalence (Mousavi et al., 2012). Type 2 diabetes mellitus is a metabolic disorder that reduces the body's ability to glucose uptake. Factors causing diabetes are still unknown, although genetic factors, obesity and the absence of physical activity have an important role in diabetes (Beckert et al., 2006). Diabetes mellitus leads to hyperglycemia, blood lipid disorders, including hypertriglyceridemia and low HDL-cholesterol and increased oxidative stress (Murarka and Movahed, 2010). Uncontrolled diabetes can cause diabetic complications, which increase medical costs and decrease quality of life (Goldberg, 2003).
1 citations
18 Apr 2019
TL;DR: The aim of the review is to categorize and summarize the available information on medicinal plants with anti-diabetic properties and suggesting outlooks for future research.
Abstract: Medicinal plants have a vast potential in the treatment of various ailments due to the presence of therapeutically important phytochemicals. Diabetes is a serious metabolic disorder and several marketed medications are available to alleviate the symptoms of diabetes. However, these over the counter drugs are expensive and associated with several complications. Herbal medicines are gaining importance as they are cost-effective and also display improved therapeutic effects with lesser side effects. The present review includes the reports available on medicinal plants used for treating diabetes complications. The aim of the review is to categorize and summarize the available information on medicinal plants with anti-diabetic properties and suggesting outlooks for future research. Based on the literature data available, a total of 81 medicinal plants with anti-diabetic, anti-hyperglycemic, hypoglycemic, anti-lipidemic and insulin mimetic properties have been compiled in this review. Further research can be carried out to study the active constituents and mechanism of these plants.
1 citations