L
Lei Yong
Researcher at Peking University
Publications - 19
Citations - 241
Lei Yong is an academic researcher from Peking University. The author has contributed to research in topics: Apoptosis & Oleandrin. The author has an hindex of 8, co-authored 17 publications receiving 160 citations.
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Inhibition of oleandrin on the proliferation and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway
TL;DR: Oleandrin exerted a strong antitumor effect on human OS cells by suppressing the Wnt/β-catenin signaling pathway, which interfered with the proliferation and invasion of OS cells, as well as induced cells apoptosis.
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Cross Talk Between Autophagy and Apoptosis Contributes to ZnO Nanoparticle‐Induced Human Osteosarcoma Cell Death
Guanping He,Yunlong Ma,Ye Zhu,Lei Yong,Xiao Liu,Peng Wang,Chen Liang,Chenlong Yang,Zhigang Zhao,Bao Hai,Xiaoyu Pan,Zhongjun Liu,Xiaoguang Liu,Chuanbin Mao,Chuanbin Mao +14 more
TL;DR: A mechanistic understanding of the NP‐directed autophagy and apoptosis in osteosarcoma cells is provided, which shows that cell viability is strongly ameliorated by the combination of inhibitors for both the late stage autophagic and the apoptosis.
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Regulation of Intrinsic and Extrinsic Apoptotic Pathways in Osteosarcoma Cells Following Oleandrin Treatment.
Yunlong Ma,Bin Zhu,Lei Yong,Chunyu Song,Xiao Liu,Huilei Yu,Peng Wang,Zhongjun Liu,Xiaoguang Liu +8 more
TL;DR: Oleandrin induced apoptosis of OS cells via activating both intrinsic and extrinsic apoptotic pathways, which was accompanied by an increase in ROS and a decrease in MMP.
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Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma
Chen Liang,Yunlong Ma,Lei Yong,Chenlong Yang,Peng Wang,Xiao Liu,Bin Zhu,Hua Zhou,Xiaoguang Liu,Zhongjun Liu +9 more
TL;DR: Data showed that YBX1 promoted tumorigenesis and progression in spinal chordoma via the EGFR/AKT pathway, which might serve as a prognostic and predictive biomarker, as well as a rational therapeutic target, for chordoma.
Journal ArticleDOI
Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway
Bao Hai,Yunlong Ma,Xiaoyu Pan,Lei Yong,Chen Liang,Guanping He,Chenlong Yang,Bin Zhu,Xiaoguang Liu +8 more
TL;DR: Melatonin mode of action was gained, which indicated its potential target signaling pathway in AF cells, and the results suggested that miR-106a-5p mediated the expression of ATG7 by directly binding to its 3′UTR inAF cells.