L
Leif A. Kirsebom
Researcher at Uppsala University
Publications - 121
Citations - 4068
Leif A. Kirsebom is an academic researcher from Uppsala University. The author has contributed to research in topics: RNase P & RNA. The author has an hindex of 39, co-authored 120 publications receiving 3898 citations. Previous affiliations of Leif A. Kirsebom include ICM Partners & Ohio State University.
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Base pairing between Escherichia coli RNase P RNA and its substrate.
TL;DR: Using compensatory mutations, the importance of Watson‐Crick complementarity between two well‐conserved residues in Escherichia coli RNase P RNA (M1 RNA), G292 and G293, and two residues in the substrate, +74C and +75C is demonstrated.
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Eukaryotic RNase P RNA mediates cleavage in the absence of protein
TL;DR: It is shown that RNase P RNAs from humans and the lower eukaryote Giardia lamblia mediate cleavage of four tRNA precursors and a model RNA hairpin loop substrate in the absence of protein, concluding that the RNA-based catalytic activity of RN enzyme P has been preserved during evolution.
Journal Article
Correction for Eukaryotic RNase P RNA mediates cleavage in the absence of protein
TL;DR: In this article, it was shown that RNase P RNAs from humans and the lower eukaryote Giardia lamblia mediate cleavage of four tRNA precursors and a model RNA hairpin loop substrate in the absence of protein.
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Recent studies of ribonuclease P.
TL;DR: Current studies of RNase P focus on structure‐function relationships with respect to interactions of the RNA subunit with its substrates and on the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
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Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects.
TL;DR: Some possible reasons underlying the structural diversity of the active sites are discussed, and they are used as thematic bases for elaborating new directions to understand how functional variations might have contributed to the complex evolution of RNase P.