L
Lennart Persson
Researcher at Uppsala University Hospital
Publications - 51
Citations - 3988
Lennart Persson is an academic researcher from Uppsala University Hospital. The author has contributed to research in topics: Microdialysis & Subarachnoid hemorrhage. The author has an hindex of 29, co-authored 51 publications receiving 3885 citations.
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Journal ArticleDOI
S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system.
Lennart Persson,H G Hårdemark,J Gustafsson,G Rundstrom,I Mendel-Hartvig,T Esscher,S. Påhlman +6 more
TL;DR: In stroke patients, the S-100 and neuron-specific enolase concentrations may reflect the extent of brain damage and could be useful in selecting patients with major stroke for more aggressive treatment during the acute phase.
Journal ArticleDOI
Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis.
Lennart Persson,Lars Hillered +1 more
TL;DR: The present study shows that microdialysis can be used for long-term measurement of extracellular fluid (ECF) energy-related metabolites and amino acids in the frontal cortex of neurosurgical patients in a clinical setting.
Journal ArticleDOI
A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury
Lawrence F. Marshall,Andrew I R Maas,Sharon Bowers Marshall,Albino Bricolo,Michael R. Fearnside,F. Iannotti,Melville R. Klauber,Jacques Lagarrigue,Ramiro D. Lobato,Lennart Persson,John D. Pickard,Jürgen Piek,Franco Servadei,Georgios N. Wellis,Gabrielle F. Morris,Eugene D. Means,Bruno Musch +16 more
TL;DR: Subgroup analysis suggested that tirilazad mesylate may be effective in reducing mortality rates in males suffering from severe head injury with accompanying treatment with a novel aminosteroid.
Journal ArticleDOI
Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain
TL;DR: This study suggests that membrane phospholipid degradation occurs in human cerebral ischaemia, and interstitial glycerol harvested by microdialysis seems to be a promising tool for monitoring of membrane lipolysis in acute brain injury.
Journal ArticleDOI
Neurochemical monitoring using intracerebral microdialysis in patients with subarachnoid hemorrhage.
Lennart Persson,Johann Valtysson,Per Enblad,Per-Erik Wärme,Kristina Giuliana Cesarini,Anders Lewén,Lars Hillered +6 more
TL;DR: The concepts that microdialysis is a promising tool for chemical monitoring of the human brain and that extracellular fluid levels of lactate, lactate/pyruvate ratio, glucose, hypoxanthine, and glutamate are useful markers of disturbances in brain energy metabolism in neurointensive care patients are supported.