L
Leonard Amaral
Researcher at Universidade Nova de Lisboa
Publications - 249
Citations - 10221
Leonard Amaral is an academic researcher from Universidade Nova de Lisboa. The author has contributed to research in topics: Efflux & Mycobacterium tuberculosis. The author has an hindex of 57, co-authored 249 publications receiving 9411 citations. Previous affiliations of Leonard Amaral include University of Lisbon & Aix-Marseille University.
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Journal ArticleDOI
Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria
Jean-Marie Pagès,Leonard Amaral +1 more
TL;DR: The description of the responsible efflux mechanism at its structural and physiological level will make it possible to develop along intelligent lines an improved new generation of EPIs that can readily be added to the armamentarium of current and past "fallen by the wayside" antibiotic therapies.
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Multidrug Efflux Pumps in Staphylococcus aureus: an Update
TL;DR: The current knowledge on MDR efflux pumps and their intricate regulatory network in Staphylococcus aureus, a major pathogen, responsible from mild to life-threatening infections is reviewed and particular emphasis is given to the potential role that S. a Aureus MDRefflux pumps, either chromosomal or plasmid-encoded, have on resistance towards different antimicrobial agents and on the selection of drug - resistant strains.
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Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species
Vannina Lorenzi,Alain Muselli,Antoine François Bernardini,Liliane Berti,Jean-Marie Pagès,Leonard Amaral,Jean-Michel Bolla +6 more
TL;DR: The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii and increases the efficacy of β-lactams, quinolones, and chloramphenicol.
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Antibiotic stress, genetic response and altered permeability of E. coli.
Miguel Viveiros,Myrielle Dupont,Liliana Rodrigues,Isabel Couto,Anne Davin-Regli,Marta Martins,Jean-Marie Pagès,Leonard Amaral +7 more
TL;DR: This study demonstrates that, in addition to the transcriptional regulation of genes coding for membrane proteins, the post-translational regulation of proteins involved in the permeability of Gram-negative bacteria also plays a major role in the physiological adaptation to antibiotic exposure.
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Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis
Diana Machado,Isabel Couto,João Perdigão,Liliana Rodrigues,Isabel Portugal,Pedro V. Baptista,Bruno Veigas,Leonard Amaral,Miguel Viveiros +8 more
TL;DR: Results support the hypothesis that activity of efflux pumps allows the maintenance of an isoniazid resistant population in a sub-optimally treated patient and should be considered in the development of new therapeutic strategies for preventing the emergence of MDR-TB during treatment.