Leonardo Brunetti

TL;DR: The development of novel FAAH inhibitors able to directly act as PPAR agonists are discussed and their promising utilization as leads for the discovery of highly effective anti-cancer compounds are discussed.

TL;DR: A review of the most recent literature regarding the discovery of secondary metabolites through isolation and structural elucidation, as well as the in vitro and/or in vivo evaluation of their biological effects is discussed in this article.

TL;DR: The whole synthesis of PZ1 in the so-called deep eutectic solvents (DESs), which have emerged as an unconventional class of bio-renewable reaction media in green synthesis, is designed and completed.

TL;DR: The significance of zinc (II) chelating agents in past and future medicinal chemistry research is focused on the importance of selectivity in order to revamp the possibility of their use in therapy, often hindered by possible side effects.

TL;DR: In this paper, the authors used tenuazonic acid (TA) as a chemical scaffold to synthesize and evaluate new derivatives (1, 2, 3, 4, 5) of the anti-AD drug donepezil, which achieved activity in the micromolar range towards all selected targets and demonstrated to be potentially orally absorbed.