L
Leonardus B.S. Kardono
Researcher at Indonesian Institute of Sciences
Publications - 80
Citations - 2610
Leonardus B.S. Kardono is an academic researcher from Indonesian Institute of Sciences. The author has contributed to research in topics: Brucea javanica & Aglaia edulis. The author has an hindex of 29, co-authored 80 publications receiving 2424 citations. Previous affiliations of Leonardus B.S. Kardono include Bandung Institute of Technology & University of Illinois at Chicago.
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Journal ArticleDOI
Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.
Leonardus B.S. Kardono,C K Angerhofer,Soefjan Tsauri,Kosasih Padmawinata,J. M. Pezzuto,A. D. Kinghorn +5 more
TL;DR: By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia and compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains.
Journal ArticleDOI
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
Bang Yeon Hwang,Bao Ning Su,Heebyung Chai,Qiuwen Mi,Leonardus B.S. Kardono,Johar J. Afriastini,Soedarsono Riswan,Bernard D. Santarsiero,Andrew D. Mesecar,Robert A. Wild,Craig R. Fairchild,Gregory D. Vite,William C. Rose,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,Steven M. Swanson,A. Douglas Kinghorn +17 more
TL;DR: Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol and episilvestrol, were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line.
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Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Bao-Ning Su,Muriel Cuendet,Michael E. Hawthorne,Leonardus B.S. Kardono,Soedarsono Riswan,Harry H. S. Fong,Rajendra G. Mehta,John M. Pezzuto,A. Douglas Kinghorn +8 more
TL;DR: From an ethyl acetate-soluble extract of the twigs of the same plant were isolated compound 4 and two new neolignan derivatives, dadahols A and B, as well as 10 known compounds, oxyresveratrol, (+)-catechin, afzelechin-3-O-alpha-L-rhamnopyranoside, resveratro, steppogenin, moracin M, isogemichalcone
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Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia.
TL;DR: By bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra collected in Indonesia, and five additional iridoids, 15-demethylplumieride, plumieride [8], alpha- allamcidin [9], beta-allamcIDin [10], and 13-O-trans-p-coumaroylplumierside [11], were obtained as inactive constituents.
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Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia
Jian Qiao Gu,Tyler N. Graf,Dongho Lee,Hee Byung Chai,Qiuwen Mi,Leonardus B.S. Kardono,Fransisca M. Setyowati,Rachman Ismail,Soedarsono Riswan,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,John M. Pezzuto,SM Swanson,David J. Kroll,Joseph O. Falkinham,Monroe E. Wall,Mansukh C. Wani,A. Douglas Kinghorn,Nicholas H. Oberlies +19 more
TL;DR: Bioactivity-directed fractionation of extracts of two Diospyros maritima bark samples from Indonesia yielded a diverse set of secondary metabolites, including a new naphthoquinone derivative, (4S)-shinanolone, and a new natural product coumarin.