Steven M. Swanson

TL;DR: Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol and episilvestrol, were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line.

TL;DR: Work has continued on the investigation of plants, collected mainly from tropical rainforests, as potential sources of new cancer chemotherapeutic agents, and a number of bioactive compounds of interest to the project are described.

TL;DR: In the present short review, selected novel compounds that have been obtained from organisms of diverse biological origin, or their derivatives, are discussed in terms of their potential use as cancer chemotherapeutic agents.

TL;DR: A unique mouse model was developed by breeding two transgenic animals that exhibited accelerated development of lesions associated with prostate cancer progression, implicating selenoproteins in cancer risk and development and raising the possibility that selenium prevents cancer by modulating the levels of these seleniproteins.

TL;DR: Based on the published data thus far, cyclopenta[b]benzofurans offer excellent potential as therapeutic agent candidates in cancer chemotherapy, even if much work still remains to be done for their further development.