L
Leopoldo Aguilera-Aguirre
Researcher at University of Texas Medical Branch
Publications - 40
Citations - 1603
Leopoldo Aguilera-Aguirre is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: DNA glycosylase & DNA repair. The author has an hindex of 22, co-authored 38 publications receiving 1238 citations. Previous affiliations of Leopoldo Aguilera-Aguirre include Universidad Michoacana de San Nicolás de Hidalgo.
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Journal ArticleDOI
Mitochondrial dysfunction increases allergic airway inflammation
Leopoldo Aguilera-Aguirre,Attila Bacsi,Attila Bacsi,Alfredo Saavedra-Molina,Alexander Kurosky,Sanjiv Sur,Istvan Boldogh +6 more
TL;DR: Observations suggest that preexisting mitochondrial dysfunction induced by oxidant environmental pollutants is responsible for the severe symptoms in allergic airway inflammation, and imply that mitochondrial defects could be risk factors and may be responsible for severe allergic disorders in atopic individuals.
Journal ArticleDOI
Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine
Istvan Boldogh,Gyorgy Hajas,Leopoldo Aguilera-Aguirre,Muralidhar L. Hegde,Zsolt Radak,Zsolt Radak,Attila Bacsi,Attila Bacsi,Sanjiv Sur,Tapas K. Hazra,Sankar Mitra +10 more
TL;DR: It is shown that OGG1 binds the 8-oxoG base with high affinity and that the complex then interacts with canonical Ras family GTPases to catalyze replacement of GDP with GTP, thus serving as a guanine nuclear exchange factor.
Journal ArticleDOI
8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors
Xueqing Ba,Xueqing Ba,Attila Bacsi,Attila Bacsi,Jixian Luo,Leopoldo Aguilera-Aguirre,Xianlu Zeng,Zsolt Radak,Zsolt Radak,Allan R. Brasier,Istvan Boldogh +10 more
TL;DR: Results show that nonproductive binding of OGG1 to 8-oxoG in promoter sequences could be an epigenetic mechanism to modulate gene expression for a prompt innate immune response.
Journal ArticleDOI
The role of 8-oxoguanine DNA glycosylase-1 in inflammation
Xueqing Ba,Xueqing Ba,Leopoldo Aguilera-Aguirre,Qura Tul Ain Nmi Rashid,Attila Bacsi,Attila Bacsi,Zsolt Radak,Zsolt Radak,Sanjiv Sur,Koa Hosoki,Muralidhar L. Hegde,Istvan Boldogh +11 more
TL;DR: The biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation are discussed.