L
Lesley Alpert
Researcher at Jewish General Hospital
Publications - 33
Citations - 1610
Lesley Alpert is an academic researcher from Jewish General Hospital. The author has contributed to research in topics: Mammary gland & Adenocarcinoma. The author has an hindex of 22, co-authored 33 publications receiving 1568 citations. Previous affiliations of Lesley Alpert include Baylor College of Medicine & McGill University.
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Journal ArticleDOI
Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells.
Ala-Eddin Al Moustafa,Moulay A. Alaoui-Jamali,Gerald Batist,Maite Hernandez-Perez,Corinne Serruya,Lesley Alpert,Martin J. Black,Robert Sladek,William D. Foulkes,William D. Foulkes +9 more
TL;DR: This study provides the first evidence that claudin-7 and connexin 31.1 are down-regulated in head and neck squamous cell carcinomas (HNSCC) compared to normal cells, and a source of potential targets for HNSCC prevention and/or therapeutics.
Journal Article
Deficiency of Connexin43 Gap Junctions Is an Independent Marker for Breast Tumors
Dale W. Laird,Paulina Fistouris,Gerald Batist,Lesley Alpert,Hung Huynh,George D. Carystinos,Moulay A. Alaoui-Jamali +6 more
TL;DR: Evidence of decreased expression of Cx43 gap junctions in breast cancer at various stages of progression as well as breast cancer cell lines is provided and the possibility that Cx 43 may be a useful marker for detecting early oncogenesis in the breast is raised.
Journal ArticleDOI
Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma
Jean-Pierre Bayley,Ivonne J. H. M. van Minderhout,Marjan M. Weiss,Jeroen C. Jansen,Peter H N Oomen,Fred H. Menko,Barbara Pasini,Barbara Ferrando,Nora Wong,Nora Wong,Lesley Alpert,Lesley Alpert,Rosie Williams,Edward Blair,Peter Devilee,Peter E.M. Taschner +15 more
TL;DR: The data indicate that germline mutations of SDHB and SDHC play a minor role in sporadic head and neck paraganglioma and further underline the importance of germline SDHB mutations in cases of familial pheochromocytoma-paragangslioma.
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Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.
TL;DR: It is found that continued agonist stimulation, and not blood pressure, is responsible for the maintained increase in gene expression and the decrease in gene Expression in the regression after drug withdrawal was gene specific.
Journal Article
Elevated DNA Repair Capacity Is Associated with Intrinsic Resistance of Lung Cancer to Chemotherapy
Nie Zeng-Rong,Jesse Paterson,Lesley Alpert,Ming-Sound Tsao,Jean Viallet,Moulay A. Alaoui-Jamali +5 more
TL;DR: Elevated DNA repair capacity is associated with drug resistance in lung cancer and modulation of DNA repair mechanism, such as the incorporation of specific DNA repair inhibitor(s) in therapeutic regimens, may help to improve therapeutic strategies of N-SCLC.