L
Leslie E. Orgel
Researcher at Salk Institute for Biological Studies
Publications - 303
Citations - 24848
Leslie E. Orgel is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nucleic acid & RNA. The author has an hindex of 80, co-authored 303 publications receiving 23937 citations. Previous affiliations of Leslie E. Orgel include Scripps Research Institute.
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Journal ArticleDOI
The formation of dipeptides from amino acids and the 2'(3')-glycyl ester of an adenylate.
Arthur L. Weber,Leslie E. Orgel +1 more
TL;DR: The yields of dipeptide obtained from the reaction of 0.2M 2′(3′)-O-(glycyl)-adenosine-5′-(O-methylphosphate) and 0.
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The formation of peptides from glycine thioesters.
Arthur L. Weber,Leslie E. Orgel +1 more
TL;DR: The yields of products from the condensation of S- glycyl-ethanethiol under similar conditions closely re-sembled those obtained with S-glycyl-N-acetylcysteamine.
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Prebiotic peptide-formation in the solid state. II. Reaction of glycine with adenosine 5'-triphosphate and P1,P2-diadenosine-pyrophosphate.
TL;DR: In this paper, the carboxyl group or glycine is activated by the ImpA formed in situ, and subsequent reactions of activated glycine leads to the formation of oligoglycines and the 2' (3')-glycylester of pA.
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Prion replication and secondary nucleation
TL;DR: The infectious agents responsible for the prion diseases appear to be aggregates of a modified form of thePrPSc that grow at the expense of the normal form, PrPC, and the mechanism of the transformation of PrPC to PrPSc is the subject of intense research interest.