L
Leslie E. Orgel
Researcher at Salk Institute for Biological Studies
Publications - 303
Citations - 24848
Leslie E. Orgel is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nucleic acid & RNA. The author has an hindex of 80, co-authored 303 publications receiving 23937 citations. Previous affiliations of Leslie E. Orgel include Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Efficient catalysis of polycytidylic acid-directed oligoguanylate formation by Pb2+☆
R. Lohrmann,Leslie E. Orgel +1 more
TL;DR: Pb 2+ is a very effective catalyst for the template-directed self-condensation of guanosine 5′-phosphorimidazolide on a polycytidylate template.
Journal ArticleDOI
Catalysts for the polymerization of adenosine cyclic 2′,3′-phosphate on a poly (U) template
TL;DR: A number of polybasic amines and glycine derivatives stabilize the triple helix formed by adenosine cyclic 2′,3′-phosphate with poly (U) and may be considered as simple models for prebiotic catalysts.
Journal ArticleDOI
The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides
TL;DR: It is shown that isolated A or T residues within an oligo(G) sequence are a complete block to copying and that an isolated C residue is copied inefficiently.
Journal ArticleDOI
Oxidative acylation using thioacids
Rihe Liu,Leslie E. Orgel +1 more
TL;DR: It is found that phenylalanine, leucine and phenylphosphate are acylated efficiently in aqueous solution by thioacetic acid and an oxidizing agent, and it is anticipated that oxidative acylation should prove to be a general method for activating carboxylic acids, including amino acids.