L
Leslie J Lipka
Publications - 1
Citations - 561
Leslie J Lipka is an academic researcher. The author has contributed to research in topics: Desmoteplase. The author has an hindex of 1, co-authored 1 publications receiving 546 citations.
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Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study.
Werner Hacke,Anthony J. Furlan,Yasir Al-Rawi,Antoni Dávalos,Jochen B. Fiebach,Franz Gruber,Markku Kaste,Leslie J Lipka,Salvador Pedraza,Peter A. Ringleb,Howard A. Rowley,Dietmar Schneider,Lee H. Schwamm,Joaquin Serena Leal,Mariola Sohngen,P. Teal,Karin Wilhelm-Ogunbiyi,Max Wintermark,Steven Warach +18 more
TL;DR: The DIAS-2 study did not show a benefit of desmoteplase given 3-9 h after the onset of stroke, and the high response rate in the placebo group could be explained by the mild strokes recorded (low baseline NIHSS scores, small core lesions, and small mismatch volumes that were associated with no vessel occlusions), which possibly reduced the potential to detect any effect.