L
Leslie R. Berry
Researcher at McMaster University
Publications - 92
Citations - 2121
Leslie R. Berry is an academic researcher from McMaster University. The author has contributed to research in topics: Antithrombin & Thrombin. The author has an hindex of 28, co-authored 91 publications receiving 2047 citations. Previous affiliations of Leslie R. Berry include Hamilton General Hospital & University Medical Center New Orleans.
Papers
More filters
Journal ArticleDOI
Mechanisms responsible for the failure of protamine to inactivate low-molecular-weight heparin.
TL;DR: Low sulphate charge, not molecular mass, is the principle reason that protamine is unable to fully inactivate LMWH, and different commercially available LMWH varied in their ability to be neutralized by protamine, and this variability correlated with the total sulphate content of the LMWH.
Journal ArticleDOI
Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta.
TL;DR: The view that heparan sulphate and dermatan sulphates could play a role similar to that of heparin in the inactivation of thrombin by antithrombin III is supported.
Journal ArticleDOI
Age-related differences in heparin response
Vera Ignjatovic,Janine Furmedge,Fiona Newall,Anthony K.C. Chan,Leslie R. Berry,Chrystal Fong,Ken Cheng,Paul Monagle,Paul Monagle +8 more
TL;DR: This study suggests that when using heparin in children, basic assumptions about the drug mechanism of action and implications for therapeutic ranges need to be considered.
Journal ArticleDOI
The structural heterogeneity of the carbohydrate moiety of desialylated human transferrin.
TL;DR: The glycan structures and their locations on the polypeptide are related to the known subpopulations of human transferrin, and they are close to the N-glycosidic triantennary glycans of bovine fetuin.
Journal ArticleDOI
Protein adsorption on polyurethane catheters modified with a novel antithrombin-heparin covalent complex.
Ying Jun Du,John L. Brash,Glen McClung,Leslie R. Berry,Petr Klement,Petr Klement,Anthony K.C. Chan +6 more
TL;DR: The ability of the resulting immobilized ATH heparin chains to bind antithrombin (AT) from plasma, as measured by binding of (125)I-radiolabeled AT, was greater than that for commercially-available Heparin-coated catheters, and much greater than for uncoatedCatheters.