L
Leszek Konieczny
Researcher at Jagiellonian University Medical College
Publications - 173
Citations - 2280
Leszek Konieczny is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Congo red & Protein structure. The author has an hindex of 26, co-authored 160 publications receiving 2104 citations. Previous affiliations of Leszek Konieczny include Jagiellonian University.
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Self‐assembly of Congo Red—A theoretical and experimental approach to identify its supramolecular organization in water and salt solutions
Marek Skowronek,Barbara Stopa,Leszek Konieczny,Rybarska J,Barbara Piekarska,Edward Szneler,G. Bakalarski,Irena Roterman +7 more
TL;DR: In this paper, the supramolecular organization of Congo Red molecules was studied to approach an understanding of the unusual complexation characteristics associated with the liquid crystalline nature of this dye.
Journal Article
Gauss-function-Based model of hydrophobicity density in proteins.
TL;DR: The model adopting the three-dimensional Gauss function to express the hydrophobicity distribution in proteins is presented and the decrease of the differences as it appears at each step of the folding simulation is the convergence criterion together with traditional non-bonding interaction optimization.
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The structure and protein binding of amyloid-specific dye reagents.
Barbara Stopa,Barbara Piekarska,Leszek Konieczny,Janina Rybarska,Paweł Spólnik,Grzegorz Zemanek,Irena Roterman,Marcin Król +7 more
TL;DR: The self-assembling tendency and protein complexation capability of dyes related to Congo red and also some dyes of different structure were compared to explain the mechanism of Congo red binding and the reason for its specific affinity for beta-structure.
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Supramolecular ligands: monomer structure and protein ligation capability.
Barbara Stopa,Magdalena Górny,Leszek Konieczny,Barbara Piekarska,Janina Rybarska,Marek Skowronek,Irena Roterman +6 more
TL;DR: The aim of this work was to define the chemical structure of compounds self-assembling in water solutions, which appear to interact with proteins as single ligands with their supramolecular nature preserved.
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Prediction of functional sites based on the fuzzy oil drop model.
Michal Brylinski,Katarzyna Prymula,Wiktor Jurkowski,Marek Kochańczyk,Ewa Stawowczyk,Leszek Konieczny,Irena Roterman +6 more
TL;DR: It is shown, based on the analyses of proteins with known biological activity and of proteins of unknown function, that the region of significantly irregular hydrophobicity distribution in proteins appears to be function related.