Showing papers in "Biochimie in 1998"

TL;DR: The objective of the present review is to provide evidence that the cell surface sialic acid serves as a determinant of the life-span and provide evidence for the existence of an alternative pathway that is independent of immunoglobulins.

TL;DR: This review deals with the historical discovery of particularly important lignan derivatives used in cancer chemotherapy, and it will be demonstrated how the activities and the ability of this class of compounds to inhibit topoisomerase II were discovered by different research teams.

TL;DR: Two long peptides, the kappa-caseinoglycopeptide and the N-terminal peptide of alpha s1- casein, were absorbed and detected in plasma, and support the concept that food-born peptides could have physiological activities in man.

TL;DR: Fluorocarbons and fluorocarbon moieties are uniquely characterized by very strong intramolecular bonds and very weak intermolecular interactions, which results in a combination of exceptional thermal, chemical and biological inertness, low surface tension, high fluidity, excellent spreading characteristics, low solubility in water, and high gas dissolving capacities, which are the basis for innovative applications in the biomedical field.

TL;DR: The fluorometric approach, using the tryptophanyl residues of the yeast carrier as intrinsic fluorescence probes, was combined to a mutagenesis approach to elucidate the ADP/ATP transport mechanism at the molecular level to develop a method to quantify the carrier protein in muscular biopsies.

TL;DR: The molecular characteristics of the protamines as well as number of protamine types present in the spermatozoon vary from species to species, and in some cases, protamine-encoding genes, although present, are not expressed to a significant level.

TL;DR: From the comparative analysis of the X-ray structures available for several families of proteins, including at least one thermophilic structure in each case, it appears that thermal stabilization is accompanied by an increase in hydrogen bonds and salt bridges.

TL;DR: Observations, together with literature data on in vivo models of central nervous system (CNS) diseases, suggest a neuroprotective role of PGE2 in pathological conditions.

TL;DR: The IRF-family may be examples of transcription factors which can selectively modulate several sets of genes depending on the cell type and/or nature of the cellular stimuli, so as to evoke host defense mechanisms against infection and oncogenesis.

TL;DR: AnxFF binding determination was combined with that of cell electrophoretic mobility, glycerol resistance and filterability to characterize RBC membrane modifications in Alzheimer's disease patients which suggested a continuous damage and regeneration in RBC of these patients.

TL;DR: Artificial fibrous proteins able to form beta-sheet crystals of defined thickness and bearing functional groups at their surface, for instance Glu residues, selenomethionine or p-fluorophenylalanine are studied.

TL;DR: The molecular interactions of camptothecin with the top1 cleavage complexes are discussed as well as the mechanisms of selective killing of cancer cells.

TL;DR: Surprisingly, for an IFN, IFN-tau is also a pregnancy-embryonic signal with paracrine antiluteolytic activity and it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2alpha ratio.

TL;DR: The data available demonstrate that at least two members of the Ifi 200 protein family, p202 and p204, inhibit cell proliferation in vitro and high constitutive levels of p204 expression impair normal embryo development in transgenic animals.

TL;DR: It is shown that IFN-delta, while being a true type I IFN, has some very specific structural and biological properties.

TL;DR: This work has shown that acetylation of sialic acid is expressed on the outer most part of the carbohydrate moiety of membrane and secreted glycoconjugates, and explains why this modification is involved in cell/cell interactions and in the non-immune protection of mucosa.

TL;DR: Data on rat and man from the laboratory and from recent literature have been thoroughly examined and compared in order to provide the 'state-of-the-art' on the role of mitochondria in aging.

TL;DR: The data indicate that NO2- + NO3- levels correlate with IFN levels and immunoreactivity, and overall suggest that IFN-gamma and nitric oxide production together play a role in the host defense mechanisms in human hydatidosis.

TL;DR: Because of their limited affinity for lipid alkyl chains and other hydrocarbon surfaces, fluorinated surfactants appear as potentially interesting tools for the study of membrane proteins that do not stand well exposure to classical detergent.

TL;DR: The last section concerns the motions involved in the allosteric transition which regulates the enzyme activity.

TL;DR: The present review is focused on the recently identified new members of cellular IRF family and their role in virus mediated response, responses and cell growth.

TL;DR: Hydropathy analysis showed that the active site of the enzyme was in an hydrophobic environment as for eukaryotic TGases, and the fact that TGase was capable to incorporate a wide variety of aliphatic and aromatic non-polar compounds suggested that the amine fixation site could be an hydrophic pocket.

TL;DR: The enzyme involved in the first step of GDP-L-fucose biosynthesis in E. coli, i.e., GDP-D-mannose 4,6 dehydratase, has been recently expressed as recombinant protein and characterized in the laboratory, thus indicating that only two enzymes are required for GDP- L- fucose production.

TL;DR: It is demonstrated that the bending modulus is strongly dependent on the membrane composition and environmental conditions and the role of transmembrane proteins is examined by measuring the bending elasticity of SOPC/gramicidin mixtures.

TL;DR: Gene expression of cathepsin D in epidermal keratinocytes resembled that of suprabasal structural proteins (involucrin, keratin K10, transglutaminase) in its response to the calcium switch.

TL;DR: The aim of this work was to define the chemical structure of compounds self-assembling in water solutions, which appear to interact with proteins as single ligands with their supramolecular nature preserved.

TL;DR: A panel of methods suitable to transform unprotected reducing oligosaccharides into glycosynthons designed to be easily linked to therapeutic agents is presented, mainly glyco-amino acids or glycopeptides.

TL;DR: After the assessment of the antitumor activity of the anthracycline pigments, the S peucetius group of metabolites was discovered and eventually doxorubicin, a major anticancer agent of established clinical usefulness was developed in the early seventies.

TL;DR: The expression in vivo of metalloproteins bound to bacterial envelope structures opens a way to design biomass with specific metal-binding properties and to endow E. coli cells an enhanced accumulation of Cd 2+ in good correlation with the number ofMetal-binding centers contributed by the MT moiety of the fusions.

TL;DR: It was shown that the commonly used strategy of oligonucleotides targeting with cationic non-viral vectors may display non-specific effects which can lead to artifactual results.