Lewis C. Strauss

TL;DR: It is shown that My-10 is expressed specifically on immature normal human marrow cells, including hematopoietic progenitor cells, as well as by leukemic marrow cells from a subpopulation of patients.

TL;DR: The anti-My-10 murine monoclonal antibody detected an epitope of a 115-kDa glycoprotein expressed specifically on KG-1a leukemia cells and a small subset of normal human bone marrow cells, providing further evidence that the My-10 molecule is expressed, at relatively low levels, selectively on early human marrow cells but not on mature lymphohematopoietic cells.

TL;DR: The My-10 antigen permits rapid identification and purification of hematopoietic progenitor cells for further study or potential clinical application, and may be a probe for differentiation-linked cellular events.

TL;DR: The study group of patients had a significantly higher risk of fungal infections than a matched group of leukemia patients treated with induction chemotherapy, and remained a significant risk factor.

TL;DR: Collective results from several laboratories indicate that CD34 monoclonal antibodies have the appropriate specificity to warrant testing their utility in positive selection for autologous bone marrow transplantation, and recent studies in very small numbers of non-human primates and human patients suggest that isolated CD34+ cells include the true hematopoietic stem cell.