S
Saul J. Sharkis
Researcher at Johns Hopkins University School of Medicine
Publications - 106
Citations - 12963
Saul J. Sharkis is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 41, co-authored 106 publications receiving 12565 citations. Previous affiliations of Saul J. Sharkis include Johns Hopkins University.
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Journal ArticleDOI
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Diane S. Krause,Neil D. Theise,Michael I. Collector,Octavian Henegariu,Sonya Hwang,Rebekah Gardner,Sara Neutzel,Saul J. Sharkis +7 more
TL;DR: It is shown that rare cells that home to bone marrow can LTR primary and secondary recipients, and this finding may contribute to clinical treatment of genetic disease or tissue repair.
Journal ArticleDOI
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Joyce E. Ohm,Kelly M. McGarvey,Xiaobing Yu,Linzhao Cheng,Kornel E. Schuebel,Leslie Cope,Helai P. Mohammad,Wei Chen,Vincent C. Daniel,Wayne Yu,David M. Berman,Thomas Jenuwein,Kevin Pruitt,Saul J. Sharkis,D. Neil Watkins,James G. Herman,Stephen B. Baylin +16 more
TL;DR: It is hypothesized that cell chromatin patterns and transient silencing of these important regulatory genes in stem or progenitor cells may leave these genes vulnerable to aberrant DNA hypermethylation and heritable gene silencing during tumor initiation and progression.
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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon Young Jang,Saul J. Sharkis +1 more
TL;DR: It is shown that an early HSC population that might reside in the low-oxygenic niche can be functionally isolated by taking advantage of the relative intracellular ROS activity and treatment with an antioxidant, a p38 inhibitor, or rapamycin was able to restore HSC function in the ROS(high) population.
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Multilineage gene expression precedes commitment in the hemopoietic system
Ming Hu,Diane S. Krause,Mel Greaves,Saul J. Sharkis,Michael Dexter,Clare M Heyworth,Tariq Enver +6 more
TL;DR: Using single cell RT-PCR, it is shown that erythroid and myeloid gene expression programs can be initiated by the same cell prior to exclusive commitment to the erythyroid or granulocytic lineages.
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Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Hsing-Chen Tsai,Huili Li,Leander Van Neste,Yi Cai,Carine Robert,Feyruz V. Rassool,James Shin,Kirsten Harbom,Robert Beaty,Emmanouil P. Pappou,James C. Harris,Ray Whay Chiu Yen,Nita Ahuja,Malcolm V. Brock,Vered Stearns,David Feller-Kopman,Lonny Yarmus,Yi Chun Lin,Alana L. Welm,Jean Pierre J. Issa,Il Minn,William Matsui,William Matsui,Yoon Young Jang,Saul J. Sharkis,Stephen B. Baylin,Stephen B. Baylin,Cynthia A. Zahnow +27 more
TL;DR: It is shown that transient exposure of cultured and primary leukemic and epithelial tumor cells to clinically relevant nanomolar doses produce an antitumor "memory" response, including inhibition of subpopulations of cancer stem-like cells.