L
Li-av Segev-Zarko
Researcher at Weizmann Institute of Science
Publications - 13
Citations - 214
Li-av Segev-Zarko is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Toxoplasma gondii & Antimicrobial peptides. The author has an hindex of 4, co-authored 6 publications receiving 152 citations.
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Journal ArticleDOI
Mechanisms of biofilm inhibition and degradation by antimicrobial peptides.
TL;DR: This study investigates how the above three steps are affected by the properties of the AMPs using a series of peptides composed of six lysines and nine leucines, which differ in their sequences and hence their biophysical properties.
Journal ArticleDOI
Temporins A and B Stimulate Migration of HaCaT Keratinocytes and Kill Intracellular Staphylococcus aureus
TL;DR: By combining antibacterial and wound-healing activities, Ta and Tb may act as multifunctional mediators of innate immunity in humans as their nonendogenous origin may reduce microbial resistance to them as well as the risk of autoimmune diseases in mammals.
Journal ArticleDOI
Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures
Stella Y. Sun,Li-av Segev-Zarko,Muyuan Chen,Grigore D. Pintilie,Michael F. Schmid,Steven J. Ludtke,John C. Boothroyd,Wah Chiu +7 more
TL;DR: The development of an advanced subtomogram averaging protocol for filamentous structures enabled us to accurately assign tubulins in cellular context and confirm to assemble into two major forms: canonical subpellicular microtubules (SPMTs) and noncanonical conoid fibrils (CFs).
Book ChapterDOI
Methods for Investigating Biofilm Inhibition and Degradation by Antimicrobial Peptides.
Li-av Segev-Zarko,Yechiel Shai +1 more
TL;DR: In this article, Cationic antimicrobial peptides (AMPs) are used as a first line of defense in defending against multidrug-resistant bacteria, and the mechanism and biophysical properties required for anti-biofilm activity are investigated.
Journal ArticleDOI
Deficient Lipid A Remodeling by the arnB Gene Promotes Biofilm Formation in Antimicrobial Peptide Susceptible Pseudomonas aeruginosa.
TL;DR: It is shown for the first time that blocking a specific lipid A modification promotesBiofilm formation, suggesting a trade-off between LPS remodeling and resistance mechanisms of biofilm formation.