M
Michael F. Schmid
Researcher at Baylor College of Medicine
Publications - 100
Citations - 4850
Michael F. Schmid is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Capsid & Cryo-electron microscopy. The author has an hindex of 36, co-authored 94 publications receiving 4245 citations. Previous affiliations of Michael F. Schmid include Stanford University & Baylor University.
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Journal ArticleDOI
Outcome of the First Electron Microscopy Validation Task Force Meeting
Richard Henderson,Andrej Sali,Matthew L. Baker,Bridget Carragher,Batsal Devkota,Kenneth H. Downing,Edward H. Egelman,Zukang Feng,Joachim Frank,Joachim Frank,Nikolaus Grigorieff,Wen Jiang,Steven J. Ludtke,Ohad Medalia,Pawel A. Penczek,Peter B. Rosenthal,Michael G. Rossmann,Michael F. Schmid,Gunnar F. Schröder,Alasdair C. Steven,David L. Stokes,John D. Westbrook,Willy Wriggers,Huanwang Yang,Jasmine Young,Helen M. Berman,Wah Chiu,Gerard J. Kleywegt,Catherine L. Lawson +28 more
TL;DR: This Meeting Review describes the proceedings and conclusions from the inaugural meeting of the Electron Microscopy Validation Validation Task Force organized by the Unified Data Resource for 3DEM and aims to increase the impact of 3DEM in biology and medicine.
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Convolutional neural networks for automated annotation of cellular cryo-electron tomograms
Muyuan Chen,Wei Dai,Stella Y. Sun,Darius Jonasch,Cynthia Y. He,Michael F. Schmid,Wah Chiu,Steven J. Ludtke +7 more
TL;DR: A method that uses neural networks to dramatically reduce the time and human effort required for subcellular annotation and feature extraction for cellular electron cryotomography is introduced.
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Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus
Dong-Hua Chen,Matthew L. Baker,Corey F. Hryc,Frank DiMaio,Joanita Jakana,Weimin Wu,Matthew T. Dougherty,Cameron Haase-Pettingell,Michael F. Schmid,Wen Jiang,David Baker,Jonathan King,Wah Chiu +12 more
TL;DR: Structural observations allow us to propose a more detailed molecular mechanism for the scaffolding-mediated capsid assembly initiation including portal incorporation, release of scaffolding proteins upon DNA packaging, and maturation into infectious virions.
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An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Zhao Wang,Guizhen Fan,Corey F. Hryc,James N. Blaza,Irina I. Serysheva,Michael F. Schmid,Wah Chiu,Ben F. Luisi,Dijun Du +8 more
TL;DR: The near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states are reported, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening.
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Interprotofilament interactions between Alzheimer's Aβ1–42 peptides in amyloid fibrils revealed by cryoEM
Rui Zhang,Xiaoyan Hu,Htet A. Khant,Steven J. Ludtke,Wah Chiu,Michael F. Schmid,Carl Frieden,Jin-Moo Lee +7 more
TL;DR: This model of mature Aβ1–42 fibrils is markedly different from previous cryoEM models of A β1–40 fibrILS, and the C terminus of Aβ forms the inside wall of the hollow core, which is supported by partial proteolysis analysis.