Li Chu

TL;DR: It is found that paeoniflorin has therapeutic potential against NAFLD and that it acts through multiple signaling pathways, including regulating lipid metabolism and exerting insulin sensitizing effect by regulating the insulin signaling pathway IRS/Akt/GSK3β and anti-oxidation.

TL;DR: Long-term treatment with fasudil could improve cardiac dysfunction, attenuate myocardial injury and prevent pathological changes in a rat model of diabetic cardiomyopathy, and these effects could be attributed to regulation of antioxidative activities, suppression of my cardiac hypertrophy, apoptosis, fibrosis and subsequent cardiac remodeling.

TL;DR: Both verapamil and nimodipine showed protection against Pb-induced kidney injury, including alleviation of renal pathological damage and decreasing the level of Pb in kidney homogenate and extent of apoptosis in nephrocytes, which implicate the therapeutic potential of CCBs for P b-induced nephrotoxicity.

TL;DR: PF has liver protective and anti-inflammatory effects in HCF diet-induced NASH rats and the possible mechanisms may be associated with inhibition of the ROCK/NF-κB signaling pathway in the NASH liver.

TL;DR: Treatment of chronic iron-overloaded mice with SM dose-dependently ameliorated changes in hepatic morphology and coefficient, and displayed anti-fibrotic activity in the liver induced by chronic iron overload, which may be attributed to multitargeted inhibition of iron deposition and collagen accumulation, as well as oxidative stress, inflammation and apoptosis.