L
Li Deng
Researcher at University of Wisconsin–Milwaukee
Publications - 9
Citations - 243
Li Deng is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Isopropyl & Pictet–Spengler reaction. The author has an hindex of 6, co-authored 9 publications receiving 239 citations.
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Journal ArticleDOI
Enantiospecific Formation of Trans 1,3-Disubstituted Tetrahydro-β-carbolines by the Pictet−Spengler Reaction and Conversion of Cis Diastereomers into Their Trans Counterparts by Scission of the C-1/N-2 Bond
Eric Cox,Linda K. Hamaker,Jin Li,Peng Yu,Kevin M. Czerwinski,Li Deng,Dennis W. Bennett,James M. Cook,William H. Watson,Mariusz Krawiec +9 more
TL;DR: The Pictet-Spengler reaction of substrates with sufficiently large substituents, followed by treatment with acid, permits the 100% enantiospecific formation of trans-1,3-disubstituted- 1,2,3,4-tetrahydro-beta-carbolines for alkaloid total synthesis.
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Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties.
TL;DR: A series of 1-substituted pyridodiindoles were synthesized and screened in vitro against [3H]diazepam for activity at the benzodiazepine receptor (BzR) and found to be the most potent (IC50 less than 10 nM) of this new class of BzR ligands.
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Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site.
Michael J. Martin,Mark L. Trudell,Hernando Diaz Arauzo,Mike Allen,Anthony J. LaLoggia,Li Deng,Christopher A. Schultz,Y.‐C. Tan,Yingzhi Bi +8 more
TL;DR: It is indicated that inverse agonists and agonists bind to the same binding region, but the pharmacophoric descriptors required for the two activities are different, in keeping with previous studies with these planar ligands.
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Mechanism driven trans stereospecificity in the Pictet-Spengler reaction. Stereospecific formation of trans-1,2,3-trisubstituted-tetrahydro β- carbolines by condensation of Nb-diphenylmethyl tryptophan isopropyl esters wtm aldehydes
TL;DR: The Pictet-Spengler condensation of N b -alkylsubstituted tryptophan alkyl esters has been employed to promote 100% stereoselectivity in this process.
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Stereospecificity in the Pictet-Spengler reaction kinetic vs thermodynamic control
TL;DR: The Pictet-Spengler reaction of N b -benzyl tryptophan methyl ester 4 with 5 in refluxing benzene yielded a mixture of cis and trans tetrahydro β-carbolines in a ratio of 7a (23)/7b (77), whereas the analogous reaction of isopropyl ester 10 with 5 provided increased trans stereoselectivity [cis(13):trans(87] as mentioned in this paper.