Showing papers by "Liang Hong published in 2011"
TL;DR: It is hypothesized that the combination of organocatalysis with organo–metal cooperative catalysis could be a valuable alternative in a cascade reaction, providing products that are difficult or impossible to obtain by the traditional approach.
Abstract: An unprecedent aza-Michael/carbocyclization reaction combining cheap and readily available α,β-unsaturated aldehydes and N-tosyl propargylamines is discovered.
56 citations
TL;DR: The asymmetric allylic substitution reaction of MBH carbonates with allylamines has been developed, which affords N-allyl-β-amino-α-methylene esters in high yields and enantioselectivities.
Abstract: The asymmetric allylic substitution reaction of MBH carbonates with allylamines has been developed, which affords N-allyl-β-amino-α-methylene esters in high yields and enantioselectivities. After a subsequent ring-closure metathesis of the products, a series of optically active 2,5-dihydropyrroles could be obtained smoothly in high yields without any loss of enantioselectivity. Finally, a tentative mechanism for rationalization of the reaction has been proposed.
47 citations
TL;DR: The development of asymmetric catalytic methods for the construction of chiral indolin-3-ones with a chiral center at the 2-position is particularly appealing.
Abstract: The asymmetric organocatalytic conjugate addition of acetylindolinone to enones constitutes an easy and efficient method for the direct preparation of substituted indolinones.
33 citations
TL;DR: The asymmetric organocatalytic conjugate addition of acetylindolinone to enones constitutes an easy and efficient method for the direct preparation of substituted indolinones as mentioned in this paper.
Abstract: The asymmetric organocatalytic conjugate addition of acetylindolinone to enones constitutes an easy and efficient method for the direct preparation of substituted indolinones.