http://uu.diva-portal.org/smash/get/diva2:1373805/FULLTEXT01

Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens.

Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert anticancer activity via various antiproliferative mechanisms, and some of them, such as Vinblastine and Vincristinem, have already used in clinics or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship, and mechanisms of action covering the articles published from 2015 to 2020.

Indole Alkaloids with Potential Anticancer Activity

Prenylated chromones and flavonoids from Artocarpus heterophyllus with their potential antiproliferative and anti-inflammatory activities.

Novel γ-lactone derivatives from Trigonostemon heterophyllus with their potential antiproliferative activities.

Novel tetrahydrofuran derivatives from Trigonostemon howii with their potential anti-HIV-1 activities.

Bioactive polyoxygenated seco-cyclohexenes from Artabotrys hongkongensis.

Cytotoxic indole alkaloids from Nauclea orientalis.

A new polyoxygenated cyclohexene derivative from Artabotrys hainanensis

A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time. These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC50 values comparable with those of cisplatin.

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200407

Liang Lai

Papers

Bioactive polyoxygenated seco-cyclohexenes from Artabotrys hongkongensis.

Cytotoxic indole alkaloids from Nauclea orientalis.

A new polyoxygenated cyclohexene derivative from Artabotrys hainanensis

Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica: