L
Liankang Sun
Researcher at Xi'an Jiaotong University
Publications - 25
Citations - 970
Liankang Sun is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Pancreatic cancer & Cancer stem cell. The author has an hindex of 14, co-authored 25 publications receiving 602 citations.
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Journal ArticleDOI
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.
Ke Chen,Weikun Qian,Zhengdong Jiang,Liang Cheng,Jie Li,Liankang Sun,Cancan Zhou,Luping Gao,Meng Lei,Bin Yan,Junyu Cao,Wanxing Duan,Qingyong Ma +12 more
TL;DR: Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC.
Journal ArticleDOI
Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression.
Wanxing Duan,Ke Chen,Zhengdong Jiang,Xin Chen,Liankang Sun,Jiahui Li,Jianjun Lei,Qinhong Xu,Jiguang Ma,Xuqi Li,Liang Han,Zheng Wang,Zheng Wu,Fengfei Wang,Erxi Wu,Qingyong Ma,Zhenhua Ma +16 more
TL;DR: Induction of AMPK activation by metformin represents a novel therapeutic approach for treating advanced PDAC through reducing the desmoplastic reaction in PDAC.
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Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1.
Cancan Zhou,Weikun Qian,Jiguang Ma,Liang Cheng,Zhengdong Jiang,Bin Yan,Jie Li,Wanxing Duan,Liankang Sun,Junyu Cao,Fengfei Wang,Erxi Wu,Zheng Wu,Qingyong Ma,Xuqi Li +14 more
TL;DR: The mechanism by which resveratrol enhanced chemosensitivity and the role of sterol regulatory element binding protein 1 (SREBP1) in gemcitabine‐induced stemness are explored.
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Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
Liang Cheng,Bin Yan,Ke Chen,Zhengdong Jiang,Cancan Zhou,Junyu Cao,Weikun Qian,Jie Li,Liankang Sun,Jiguang Ma,Qingyong Ma,Huanchen Sha +11 more
TL;DR: It is demonstrated that resveratrol suppresses the expression of NAF-1 in pancreatic cancer cells by inducing cellular reactive oxygen species (ROS) accumulation and activating Nrf2 signaling, which can improve the sensitivity of pancreaticcancer cells to gemcitabine.
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Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway.
Ke Chen,Weikun Qian,Jie Li,Zhengdong Jiang,Liang Cheng,Bin Yan,Junyu Cao,Liankang Sun,Cancan Zhou,Meng Lei,Wanxing Duan,Jiguang Ma,Qingyong Ma,Zhenhua Ma +13 more
TL;DR: A novel mechanism by which the loss of AMPK activation amplifies the activity of HSF1 to promote the invasion and metastasis of pancreatic cancer is revealed.