L
Libo Zheng
Researcher at Hebei Medical University
Publications - 19
Citations - 727
Libo Zheng is an academic researcher from Hebei Medical University. The author has contributed to research in topics: Fibrosis & Hepatic stellate cell. The author has an hindex of 11, co-authored 17 publications receiving 586 citations. Previous affiliations of Libo Zheng include Cedars-Sinai Medical Center.
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Journal ArticleDOI
Immunopathology of inflammatory bowel disease.
TL;DR: The host microbiome, as well as viruses and fungi, play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.
Journal ArticleDOI
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.
David Q. Shih,Libo Zheng,Xiaolan Zhang,Hong Zhang,Yoshitake Kanazawa,Ryan Ichikawa,Kori Wallace,Jeremy Chen,Charalabos Pothoulakis,Hon Wai Koon,Stephan R. Targan +10 more
TL;DR: Treatment with neutralizing Tl1a Ab reversed colonic fibrosis back to the original pre-inflamed levels and demonstrated a direct role for TL1a–DR3 signaling in tissue fibrosis and that modulation of TL1A– DR3 signaling could inhibit gut fibrosis.
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In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: Therapeutic effect on liver fibrosis/cirrhosis.
TL;DR: Transplanted hUC-MSCs could differentiate into functional hepatocytes that improved both the biochemical and histopathologic changes in a CCl4-induced rat liver fibrosis model, and may offer therapeutic opportunities for treating hepatobiliary diseases, including cirrhosis.
Journal ArticleDOI
Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.
Hong Zhang,Hong Zhang,Libo Zheng,Dermot P.B. McGovern,Ariel M. Hamill,Ryan Ichikawa,Yoshitake Kanazawa,Justin Luu,Kotaro Kumagai,Marianne Cilluffo,Masayuki Fukata,Stephan R. Targan,David M. Underhill,Xiaolan Zhang,David Q. Shih +14 more
TL;DR: It is revealed that ATG16L1 deficiency led to alterations in macrophage function that contribute to the severity of CD.
Journal ArticleDOI
Sustained tl1a (tnfsf15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis.
Libo Zheng,Xiaolan Zhang,Jeremy J.W. Chen,Ryan Ichikawa,Kori Wallace,Charalabos Pothoulakis,Hon Wai Koon,Stephan R. Targan,David Q. Shih +8 more
TL;DR: It is confirmed that TL1A-DR3 interaction is involved in T cell-dependent ileitis and fibrosis, and T cells with constitutive expression of Tl1a in both lymphoid and myeloid cells were found to have a more activated phenotype and increased gut homing marker CCR9 expression.