D
David Q. Shih
Researcher at Cedars-Sinai Medical Center
Publications - 129
Citations - 4254
David Q. Shih is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Inflammatory bowel disease & Colitis. The author has an hindex of 31, co-authored 124 publications receiving 3595 citations.
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Journal ArticleDOI
Immunopathology of inflammatory bowel disease.
TL;DR: The host microbiome, as well as viruses and fungi, play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.
Journal ArticleDOI
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
Dermot P.B. McGovern,Matthew Jones,Kent D. Taylor,Kristin D. Marciante,Xiaofei Yan,Marla Dubinsky,Andrew Ippoliti,Eric A. Vasiliauskas,Dror Berel,Carrie Derkowski,Deb Dutridge,Phil Fleshner,David Q. Shih,Gil Y. Melmed,Emebet Mengesha,Lily King,Sheila Pressman,Talin Haritunians,Xiuqing Guo,Stephan R. Targan,Jerome I. Rotter +20 more
TL;DR: In this paper, the authors performed a genome-wide association study (GWAS) in 896 Crohn's disease (CD) cases and 3204 healthy controls all of Caucasian origin as defined by multidimensional scaling.
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Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice
Hongwei Zhao,Hong Zhang,Hui Wu,Hui Li,Lei Liu,Jian Guo,Chenyang Li,David Q. Shih,Xiaolan Zhang +8 more
TL;DR: 1,25(OH)2D3 may play a protective role in mucosal barrier homeostasis by maintaining the integrity of junction complexes and in healing capacity of the colon epithelium.
Journal ArticleDOI
Immunopathogenesis of inflammatory bowel disease
David Q. Shih,Stephan R. Targan +1 more
TL;DR: Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis.
Journal ArticleDOI
The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery.
Cheryl C. Lau,Marla Dubinsky,Gil Y. Melmed,Eric A. Vasiliauskas,Dror Berel,Dermot P.B. McGovern,Andrew Ippoliti,David Q. Shih,Stephan R. Targan,Phillip Fleshner +9 more
TL;DR: Increasing preoperative serum anti-TNFα drug levels are associated with adverse postoperative outcomes in CD but not UC patients.