L
Lihong Wang
Researcher at Peking Union Medical College
Publications - 23
Citations - 539
Lihong Wang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Cariporide & Intracellular pH. The author has an hindex of 12, co-authored 23 publications receiving 363 citations. Previous affiliations of Lihong Wang include Harbin Medical University.
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Journal ArticleDOI
Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.
Fan Yang,Ying Qin,Yueqiu Wang,Songyan Meng,Huimin Xian,Hui Che,Hui Che,Jie Lv,Yang Li,Yahan Yu,Yunlong Bai,Yunlong Bai,Lihong Wang,Lihong Wang +13 more
TL;DR: Investigating whether metformin can inhibit the NLRP3 inflammasome by activating the AMPK/mTOR pathway in diabetic cardiomyopathy found that it can activate AMPK, thus improving autophagy via inhibiting the mTOR pathway and alleviating pyroptosis in DCM.
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NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.
Yani Lin,Guoqiang Chang,Jian Wang,Wei-Na Jin,Lihong Wang,Hua-Wen Li,Li Ma,Qinghua Li,Tianxiang Pang +8 more
TL;DR: It is shown here that inhibition of NHE1 activity, with specific inhibitor Cariporide, could suppress MDA-MB-231 cells invasion as well as the activity and expression of MT1-MMP, and the role of MAPK signaling pathways in N HE1-mediated breast cancer metastasis is explored.
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Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients
TL;DR: It is confirmed that FLT3 activating mutations also occur in a significant percentage in Chinese AML patients, and patients treated with standard induction regimen could achieve lower complete remission rates compared with patients not harboring this defect.
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Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF‐β1/Smad signaling
Songyan Meng,Fan Yang,Yueqiu Wang,Ying Qin,Huimin Xian,Hui Che,Hui Che,Lihong Wang,Lihong Wang +8 more
TL;DR: Data demonstrate that silymarin ameliorates DCM through the inhibition of TGF‐β1/Smad signaling, suggesting that sallymarin may be a potential target for DCM treatment.
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Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF
Wei Gao,Guoqiang Chang,Jian Wang,Wei-Na Jin,Lihong Wang,Yani Lin,Hua-Wen Li,Li Ma,Qinghua Li,Tianxiang Pang +9 more
TL;DR: The proliferation, migration and in vitro tube formation of human umbilical vein endothelial cells was decreased in cariporide treated K562 condition medium (CM) while VEGF supplement could partially restore the inhibitory effect.