Y
Yang Li
Researcher at Harbin Medical University
Publications - 28
Citations - 847
Yang Li is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Arthritis & Diabetic cardiomyopathy. The author has an hindex of 11, co-authored 25 publications receiving 433 citations.
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Journal ArticleDOI
Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.
Fan Yang,Ying Qin,Yueqiu Wang,Songyan Meng,Huimin Xian,Hui Che,Hui Che,Jie Lv,Yang Li,Yahan Yu,Yunlong Bai,Yunlong Bai,Lihong Wang,Lihong Wang +13 more
TL;DR: Investigating whether metformin can inhibit the NLRP3 inflammasome by activating the AMPK/mTOR pathway in diabetic cardiomyopathy found that it can activate AMPK, thus improving autophagy via inhibiting the mTOR pathway and alleviating pyroptosis in DCM.
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Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis.
TL;DR: The identity of monocytes, the antigenic expression on monocyte surface and their cytokines role in RA are enlightened, and monocytes are the circulating precursors of macrophages and osteoclasts in RA.
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Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Hui Che,Yueqiu Wang,Hui Li,Yang Li,Abbas Sahil,Jie Lv,Yining Liu,Zhenyu Yang,Ruixue Dong,Hongru Xue,Lihong Wang +10 more
TL;DR: Findings indicate that melatonin produces an antifibrotic effect via inhibiting lncR‐MALAT1/miR‐141‐mediated NLRP3 inflammasome activation and TGF‐β1/Smads signaling, and it might be considered a potential agent for the treatment of DCM.
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A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA.
Fan Yang,Anqi Li,Ying Qin,Hui Che,Yueqiu Wang,Jie Lv,Yang Li,Hui Li,Er Yue,Xueying Ding,Yahan Yu,Yunlong Bai,Yunlong Bai,Lihong Wang,Lihong Wang +14 more
TL;DR: This study identified that hsa_circ_0076631, named caspase-1-associated circRNA (CACR), was increased both in high-glucose-treated cardiomyocytes and in the serum of diabetic patients, and elucidated that CACR might be a novel therapeutic target via the C ACR/miR-214-3p/casp enzyme-1 pathway in DCM.
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LncRNA H19 promotes triple-negative breast cancer cells invasion and metastasis through the p53/TNFAIP8 pathway.
TL;DR: Insight is provided into a novel mechanism of lncRNA H19 in tumorigenesis and metastases of breast cancer and H19/p53/TNFAIP8 axis is demonstrated as a promising therapeutic target for breast cancer, especially for TNBC.