Yuming Yang,†,§ Qiang Zhao,‡,§ Wei Feng,† and Fuyou Li*,† †Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China ‡Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210046, P. R. China.

Luminescent chemodosimeters for bioimaging.

Exposure to even very low levels of lead, cadmium, and mercury ions is known to cause neurological, reproductive, cardiovascular, and developmental disorders, which are more serious problems for children particularly. Accordingly, great efforts have been devoted to the development of fluorescent and colorimetric sensors, which can selectively detect lead, cadmium, and mercury ions. In this critical review, the fluorescent and colorimetric sensors are classified according to their receptors into several categories, including small molecule based sensors, calixarene based chemosensors, BODIPY based chemosensors, polymer based chemosensors, DNA functionalized sensing systems, protein based sensing systems and nanoparticle based sensing systems (197 references).

Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions

Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives Xiaoqiang Chen, Tuhin Pradhan, Fang Wang, Jong Seung Kim,* and Juyoung Yoon* Departments of Chemistry and Nano Science and of Bioinspired Science (WCU), Ewha Womans University, Seoul 120-750, Korea State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China Department of Chemistry, Korea University, Seoul 136-701, Korea

Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives.

Design strategies for water-soluble small molecular chromogenic and fluorogenic probes.

Detection Ying Zhou,†,‡ Jun Feng Zhang, and Juyoung Yoon*,† †Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea ‡Key Laboratory of Medicinal Chemistry for Natural Resource, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, P. R. China

Fluorescence and colorimetric chemosensors for fluoride-ion detection.

To realize highly selective relay recognition of Cu2+ and sulfide ions, a simple benzimidazole-based fluorescent chemosensor (1) was designed and synthesized. Sensor 1 displays rapid, highly selective and sensitive recognition to Cu2+ in 100% water solution at pH 6.0. The in situ generated 1-Cu2+ complex solution exhibit a fast response and high selectivity toward sulfide anion via Cu2+ displacement approach. The detection limits of sensor 1 to Cu2+ and 1-Cu2+ complex to sulfide anion were estimated to be 3.5 × 10−7 M and 1.35 × 10−6 M, respectively. Proof-of-concept experiment results demonstrate that sensor 1 has potential utilities for Cu2+ and sulfide ion concentration evaluation in real water samples. This successive recognition feature of sensor 1 makes it has a potential utility for Cu2+ and sulfide anion detection in water.

Rapid and highly selective relay recognition of Cu(II) and sulfide ions by a simple benzimidazole-based fluorescent sensor in water

Single sensor for two metal ions: colorimetric recognition of Cu2+ and fluorescent recognition of Hg2+.

A new benzimidazole-based imine linked sensor ( 1 ) was synthesized. Sensor 1 exhibits highly selective and sensitive recognition properties to Cu 2+ in CH 3 OH/H 2 O (1/1, v/v, HEPES 10 mM, pH = 7.0) solution with a 1:1 binding stoichiometry. The in situ prepared 1 –Cu 2+ complex solution displays high selectivity to cyanide through Cu 2+ displacement approach and possesses excellent tolerance to other common interference anions. The detection limits of sensor 1 to Cu 2+ and 1 –Cu 2+ complex to cyanide were estimated to be 1.82 × 10 −8  M and 1.62 × 10 −6  M, respectively. This Cu 2+ and cyanide successive recognition feature of sensor 1 makes it a potential utility for Cu 2+ and cyanide detection in aqueous media.

A highly selective and sensitive fluorescent sensor for Cu2+ and its complex for successive sensing of cyanide via Cu2+ displacement approach

Sequential recognition of Cu 2+ and CN − by a new benzimidazole-containing quinazoline based probe (1) has been achieved. Probe 1 exhibits highly selective and sensitive fluorescence “off-on” recognition properties to Cu 2+ in CH 3 CH 2 OH/H 2 O (1/1, v/v, HEPES 20 mM, pH 7.0) solution with a 2:1 binding stoichiometry. The in situ prepared 1-Cu 2+ complex solution displays high selectivity to CN − through fluorescence relay enhancement. This Cu 2+ and CN − sequential recognition via fluorescence relay enhancement make probe 1 has a potential utility for Cu 2+ and CN − detection in aqueous media.

Lijun Tang

Papers

Rapid and highly selective relay recognition of Cu(II) and sulfide ions by a simple benzimidazole-based fluorescent sensor in water

Single sensor for two metal ions: colorimetric recognition of Cu2+ and fluorescent recognition of Hg2+.

A highly selective and sensitive fluorescent sensor for Cu2+ and its complex for successive sensing of cyanide via Cu2+ displacement approach

Fluorescence relay enhancement sequential recognition of Cu2+ and CN− by a new quinazoline derivative

An ESIPT-based mitochondria-targeted ratiometric and NIR-emitting fluorescent probe for hydrogen peroxide and its bioimaging in living cells