Lil Träskman

TL;DR: Both 5HIAA and HVA were positively and significantly correlated to platelet MAO activity in the healthy subjects, but not in any of the patient groups.

TL;DR: The biochemical and antidepressant effects of chlorimipramine (Cl) were studied in depressed patients after 3 wk of treatment as discussed by the authors, and the patients were subdivided into two groups, those with low and those with high CSF 5-HIAA.

TL;DR: The factors that contributed most to the variance in CSF cortisol levels were a diagnosis of depression, height, and important life changes during the six months preceding the investigation.

TL;DR: The effects of chlorimipramine on the concentrations of the main metabolites of serotonin (5‐HT) norepinephrine (NE), and dopamine, and homovanillic acid (HVA), respectively, were studied in cerebrospinal fluid from 14 depressed patients, and related to the serotonin‐ and NE uptake inhibiting activity in vitro of plasma drawn from the patients.

TL;DR: The present series of studies of CSF monoamine metabolites support the hypothesis of a role for serotonin in depressive illness, insofar that depressed patients have slightly lower CSF 5-HIAA concentrations than normal controls.