L
Liliane Tenenbaum
Researcher at University of Lausanne
Publications - 58
Citations - 2313
Liliane Tenenbaum is an academic researcher from University of Lausanne. The author has contributed to research in topics: Neurotrophic factors & Gene delivery. The author has an hindex of 24, co-authored 58 publications receiving 2003 citations. Previous affiliations of Liliane Tenenbaum include Free University of Brussels & University Hospital of Lausanne.
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Tet-On Systems For Doxycycline-inducible Gene Expression.
TL;DR: ADox-controlled HIV-1 variant was designed and used to greatly improve the activity and dox-sensitivity of the rtTA transcriptional activator component of the Tet-On system and will reduce side effects and allow gene control in tissues where a relatively low dox level can be reached, such as the brain.
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Recombinant AAV‐mediated gene delivery to the central nervous system
Liliane Tenenbaum,Abdelwahed Chtarto,Enni Lehtonen,Thierry Velu,Jacques Brotchi,Marc Levivier +5 more
TL;DR: Recombinant AAV4‐mediated gene transfer was inefficient in neurons and glial cells of the striatum but efficient in ependymal cells and hybrids such as the chicken β‐actin/CMV promoter resulted in sustained transgene expression.
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Clinical potential of minocycline for neurodegenerative disorders.
TL;DR: The present review summarizes the available data supporting the clinical testing of minocycline for Huntington's disease, amyotrophic lateral sclerosis and Parkinson's disease and extends the discussion to the potential applications of minicelline for combining this treatment with cellular and molecular therapy.
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Evaluation of risks related to the use of adeno-associated virus-based vectors.
TL;DR: A correlation between early abortion as well as male infertility and the presence of wt AAV DNA in the genital tract has been suggested and this issue stresses the importance of using rAAV stocks devoid of contaminating replication-competent AAV.
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Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor
Bas Blits,Thomas P. Carlstedt,Marc J. Ruitenberg,Fred de Winter,Wim T. J. M. C. Hermens,Paul A. Dijkhuizen,Jill W. C. Claasens,Ruben Eggers,Ronald van der Sluis,Liliane Tenenbaum,Gerard J. Boer,Joost Verhaagen +11 more
TL;DR: AAV-mediated overexpression of GDNF and BDNF in the spinal cord persisted for at least 16 weeks and at both 1 and 4 months post-lesion AAV-BDNF- and -GDNF-treated animals showed an increased survival of motoneurons, the effect being more prominent at 1 month.