L
Lin Yang
Researcher at Fudan University
Publications - 84
Citations - 803
Lin Yang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 11, co-authored 61 publications receiving 381 citations. Previous affiliations of Lin Yang include Boston Children's Hospital & Zhejiang University.
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Journal ArticleDOI
Clinical and genetic spectrum of a large cohort of children with epilepsy in China.
Lin Yang,Yanting Kong,Xinran Dong,Liyuan Hu,Yifeng Lin,Xiang Chen,Qi Ni,Yulan Lu,Bingbing Wu,Huijun Wang,Q. Richard Lu,Wenhao Zhou +11 more
TL;DR: The 12 most commonly implicated genes in this cohort and the genes with treatment options should be considered as part of the essential panel for early diagnosis of epilepsy onset, if large medical exome analyses or ES are not feasible as first-tier analysis.
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Psychiatric illness and intellectual disability in the Prader-Willi syndrome with different molecular defects--a meta analysis.
TL;DR: Significant different clinical features of cognitive development and psychiatric illness are associated with the Prader–Willi syndrome with different molecular defects.
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Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort
Xinran Dong,Bo Liu,Lin Yang,Huijun Wang,Bingbing Wu,Renchao Liu,Hongbo Chen,Xiang Chen,Sha Yu,Bin Chen,Sujuan Wang,Xiu Xu,Wenhao Zhou,Yulan Lu +13 more
TL;DR: With a higher diagnostic rate, more comprehensive observation of variations and lower cost compared with conventional strategies, simultaneous analysis of CNVs and SNVs based on CES showed potential as a new first-tier choice to diagnose DD.
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Optimized trio genome sequencing (OTGS) as a first-tier genetic test in critically ill infants: practice in China.
Huijun Wang,Yulan Lu,Xinran Dong,Guoping Lu,Guoqiang Cheng,Yanyan Qian,Qi Ni,Ping Zhang,Lin Yang,Bingbing Wu,Wenhao Zhou +10 more
TL;DR: High-capacity OTGS testing in detecting SNVs and chromosomal abnormalities with fast response, higher diagnostic yield, and lower cost demonstrates the potential to be the first-tier of genetic testing used in critically ill infants in developing countries.
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Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants.
Huijun Wang,Yanyan Qian,Yulan Lu,Qian Qin,Guoping Lu,Guoqiang Cheng,Ping Zhang,Lin Yang,Bingbing Wu,Wenhao Zhou +9 more
TL;DR: The 24-h trio-exome sequencing (TES) can serve as a rapid response tool for patients with suspected monogenic disorders and can guide clinical decision-making in urgent cases.